RGS20

From Wikipedia, the free encyclopedia
Jump to: navigation, search
RGS20
Identifiers
Aliases RGS20, RGSZ1, ZGAP1, g(z)GAP, gz-GAP, regulator of G-protein signaling 20
External IDs MGI: 1929866 HomoloGene: 2745 GeneCards: RGS20
RNA expression pattern
PBB GE RGS20 210138 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286673
NM_001286674
NM_001286675
NM_003702
NM_170587

NM_001177795
NM_001290372
NM_021374

RefSeq (protein)

NP_001273602
NP_001273603
NP_001273604
NP_003693
NP_733466

NP_001277301.1
NP_067349.2
NP_001171266
NP_001277301
NP_067349

Location (UCSC) Chr 8: 53.85 – 53.96 Mb Chr 1: 4.91 – 5.07 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.[3][4][5]

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM][5]

In melanocytic cells RGS20 gene expression may be regulated by MITF.[6]

Interactions[edit]

RGS20 has been shown to interact with GNAO1[7] and GNAZ.[3][8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Glick JL, Meigs TE, Miron A, Casey PJ (Nov 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". J Biol Chem. 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. PMID 9748279. 
  4. ^ Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (Nov 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". J Biol Chem. 273 (40): 26014–25. doi:10.1074/jbc.273.40.26014. PMID 9748280. 
  5. ^ a b "Entrez Gene: RGS20 regulator of G-protein signalling 20". 
  6. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  7. ^ Pagano, Mario; Jordan J Dedrick; Neves Susana R; Nguyen Tracy; Iyengar Ravi (Jun 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cell. Signal. England. 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. ISSN 0898-6568. PMC 3107604Freely accessible. PMID 18407463. 
  8. ^ Nagahama, Masami; Usui Shihomi; Shinohara Takashi; Yamaguchi Tomohiro; Tani Katsuko; Tagaya Mitsuo (Dec 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell. Sci. England. 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. ISSN 0021-9533. PMID 12414994. 

Further reading[edit]