RIF1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
RIF1
Identifiers
Aliases RIF1, replication timing regulatory factor 1
External IDs MGI: 1098622 HomoloGene: 41231 GeneCards: RIF1
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for RIF1
Genomic location for RIF1
Band 2q23.3 Start 151,409,883 bp[1]
End 151,508,013 bp[1]
RNA expression pattern
PBB GE RIF1 214700 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001177663
NM_001177664
NM_001177665
NM_018151

NM_175238
NM_001355414
NM_001355415

RefSeq (protein)

NP_001171134
NP_001171135
NP_001171136
NP_060621

NP_780447
NP_001342343
NP_001342344

Location (UCSC) Chr 2: 151.41 – 151.51 Mb Chr 2: 52.07 – 52.12 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.[5][6][7]

RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.[8] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080345 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036202 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T (September 2004). "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint". Genes & Development. 18 (17): 2108–19. doi:10.1101/gad.1216004. PMC 515289Freely accessible. PMID 15342490. 
  6. ^ Adams IR, McLaren A (April 2004). "Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells". Developmental Dynamics. 229 (4): 733–44. doi:10.1002/dvdy.10471. PMID 15042697. 
  7. ^ "Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)". 
  8. ^ Ribeyre C, Shore D (2012). "Anticheckpoint pathways at telomeres in yeast". Nature Structural & Molecular Biology. 19 (3): 307–13. doi:10.1038/nsmb.2225. PMID 22343724. 
  9. ^ Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA (2016-01-01). "Serial interactome capture of the human cell nucleus". Nature Communications. 7: 11212. doi:10.1038/ncomms11212. PMC 4822031Freely accessible. PMID 27040163. 

Further reading[edit]