MST4

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  (Redirected from RP6-213H19.1)
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STK26
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases STK26, MASK, MST4, serine/threonine protein kinase 26
External IDs MGI: 1917665 HomoloGene: 84402 GeneCards: STK26
RNA expression pattern
PBB GE RP6-213H19.1 218499 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042452
NM_001042453
NM_016542

NM_133729
NM_001313744

RefSeq (protein)

NP_001035917
NP_001035918
NP_057626

NP_001300673.1
NP_598490.1
NP_001300673
NP_598490

Location (UCSC) Chr X: 132.02 – 132.08 Mb Chr X: 50.84 – 50.89 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene.[3]

Function[edit]

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[3]

Interactions[edit]

RP6-213H19.1 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4". 
  4. ^ a b c d e f g Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004Freely accessible. PMID 18782753. 

Further reading[edit]