RX2 or variant may refer to:
- Mazda RX-2 midsized car
- .rx2 file format
- RX II sailing yacht
- Lublin R-XII airplane
- RX2 minor planet notation
- RX-2, a character from Garfield, see A Garfield Character
- RX2, a product from iZotope
- RX-2, a grand piano from Kawai (company)
- RX2, the differential from the Renault Captur
- RX02, a pharmaceutical from Rib-X Pharmaceuticals
- DEC RX02, 8"-floppy system, see List of floppy disk formats
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