Rexed laminae

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Medulla spinalis - Substantia grisea
Rexed lamina

The Rexed laminae comprise a system of ten layers of grey matter (I-X), identified in the early 1950s by Bror Rexed to label portions of the grey columns of the spinal cord.[1][2]

Similar to Brodmann areas, they are defined by their cellular structure rather than by their location, but the location still remains reasonably consistent[citation needed].


  • Posterior/dorsal horn: I-VI
    • Lamina I: marginal nucleus of spinal cord or posteromarginal nucleus
    • Lamina II: substantia gelatinosa of Rolando
    • Laminae III and IV: nucleus proprius
    • Lamina V: Neck of the dorsal horn. Neurons within lamina V are mainly involved in processing sensory afferent stimuli from cutaneous, muscle and joint mechanical nociceptors as well as visceral nociceptors. This layer is home to wide dynamic range tract neurons, interneurons and propriospinal neurons. Viscerosomatic pain signal convergence often occurs in this lamina due to the presence of wide dynamic range tract neurons resulting in pain referral.[3]
    • Lamina VI: Base of the dorsal horn. 'Fast pain' moves to lamina VI, which controls flexion reflex (i.e. withdrawal from painful stimulus).[4]
  • Intermediate zone: VII and X
  • Anterior/ventral horn: VIII-IX
  • Centrally
    • Lamina X: Central Zone, grey matter surrounding the central canal


  1. ^ Rexed B (1952). "The cytoarchitectonic organization of the spinal cord in the cat.". J Comp Neurol. 96 (3): 414–95. PMID 14946260. doi:10.1002/cne.900960303. 
  2. ^ Rexed B (1954). "A cytoarchitectonic atlas of the spinal cord in the cat.". J Comp Neurol. 100 (2): 297–379. PMID 13163236. doi:10.1002/cne.901000205. 
  3. ^ Darby, Susan A., and Cramer, Gregory D. (2013). Clinical Anatomy of the Spine, Spinal Cord and ANS. Saint Louis, MO, USA: Mosby. pp. 341–413. ISBN 978-0323079549. 
  4. ^ Woolsey, Robert M.; Vernon W. Lin; Cardenas, Diana D.; Cutter, Nancy C.; Frederick S. Frost; Margaret C. Hammond; Laurie B. Lindblom; Inder Perkash; Robert Waters (2002). Spinal Cord Medicine: Principles and Practice. Demos Medical Publishing. ISBN 1-888799-61-7. 
  5. ^ a b c Blumenfeld, Hal (2010). Neuroanatomy through Clinical Cases. Sunderland, MA: Sinauer Associates.