Rne-II RNA motif
Consensus secondary structure of rne-II RNAs
|RNA type||Cis-regulatory element|
The rne-II RNA motif is a conserved RNA structure identified using bioinformatics. It is detected only in species classified within the family Pseudomonadaceae, a group of gammaproteobacteria. rne-II RNAs are consistently located in the presumed 5' untranslated regions (5' UTRs) of genes that encode Ribonuclease E (RNase E). The RNase E 5' UTR element is a previously identified RNA structure that is also found in the 5' UTRs of RNase E genes. However, the latter motif is found only in enterobacteria, and the two motifs have apparently unrelated structure. In view of their differences, it was hypothesized that rne-II RNAs fulfill the same functional role as RNase E 5' UTR elements, which is to regulate the levels of RNase E proteins by acting as a substrate for RNase E. Thus, when concentrations of RNase E are high, they will degrade their own messenger RNA.
- Weinberg Z, Wang JX, Bogue J, et al. (March 2010). "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes". Genome Biol. 11 (3): R31. doi:10.1186/gb-2010-11-3-r31. PMC . PMID 20230605.
|This molecular or cell biology article is a stub. You can help Wikipedia by expanding it.|