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SUMO1 activating enzyme subunit 1
Protein SAE1 PDB 1y8q.png
PDB rendering based on 1y8q.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SAE1 ; AOS1; HSPC140; SUA1; UBLE1A
External IDs OMIM613294 MGI1929264 HomoloGene4019 ChEMBL: 1615388 GeneCards: SAE1 Gene
RNA expression pattern
PBB GE SAE1 217946 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10055 56459
Ensembl ENSG00000142230 ENSMUSG00000052833
UniProt Q9UBE0 Q9R1T2
RefSeq (mRNA) NM_001145713 NM_001285891
RefSeq (protein) NP_001139185 NP_001272820
Location (UCSC) Chr 19:
47.62 – 47.71 Mb
Chr 7:
16.33 – 16.39 Mb
PubMed search [1] [2]

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.[1][2][3][4]


SAE1 has been shown to interact with SAE2.[1][3][5][6]


  1. ^ a b Desterro JM, Rodriguez MS, Kemp GD, Hay RT (May 1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 10618–24. doi:10.1074/jbc.274.15.10618. PMID 10187858. 
  2. ^ Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H (Mar 1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803. 
  3. ^ a b Gong L, Li B, Millas S, Yeh ET (Jun 1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett. 448 (1): 185–9. doi:10.1016/S0014-5793(99)00367-1. PMID 10217437. 
  4. ^ "Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1". 
  5. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

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