SCH-202,596

SCH-202,596
Clinical data
ATC code	none;
Identifiers
	IUPAC name methyl (2S)-5,7-dichloro-5'-methoxy-6-methyl-3,3'-dioxo-4-([(1R,4R,5R,6S)-4,5,6-trihydroxy-2-methoxycarbonyl-1-cyclohex-2-enyl]oxy)spiro[1-benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylate;
CAS Number	196615-89-1;
PubChem CID	11758032;
IUPHAR/BPS	6128;
CompTox Dashboard (EPA)	DTXSID401032022 ;
Chemical and physical data
Formula	C25H22Cl2O12
Molar mass	585.340 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC(=O)C4=CC(O)C(O)C(O)C4Oc3c(C1=O)c(c(Cl)c(C)c3Cl)OC12C(C(=O)OC)=CC(=O)C=C2OC;

SCH-202,596 is a natural product which is a metabolite derived from an Aspergillus fungus. It acts as a selective non-peptide antagonist for the receptor GAL-1, which is usually activated by the neuropeptide galanin. SCH-202,596 is used for scientific research into this still little characterised receptor subtype.^[1]^[2]

References

^ Min C, et al. A New Fungal Metabolite, Sch 202596, with Inhibitory Activity in the Galanin Receptor GALR1 Assay. Tetrahedron Letters 1997; 38(35):6111–6114. doi:10.1016/S0040-4039(97)01385-3
^ Katoh T, et al. Synthetic studies on Sch 202596, an antagonist of the galanin receptor subtype GalR1: an efficient synthesis of (±)-geodin, the spirocoumaranone part of Sch 202596. Tetrahedron 2002; 58(7):1289–1299.

Template:Neuropeptidergics

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[1] Min C, et al. A New Fungal Metabolite, Sch 202596, with Inhibitory Activity in the Galanin Receptor GALR1 Assay. Tetrahedron Letters 1997; 38(35):6111–6114. doi:10.1016/S0040-4039(97)01385-3

[2] Katoh T, et al. Synthetic studies on Sch 202596, an antagonist of the galanin receptor subtype GalR1: an efficient synthesis of (±)-geodin, the spirocoumaranone part of Sch 202596. Tetrahedron 2002; 58(7):1289–1299.

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