Galanin receptor 1

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Galanin receptor 1
External IDs OMIM600377 MGI1096364 HomoloGene74396 IUPHAR: 243 ChEMBL: 4894 GeneCards: GALR1 Gene
RNA expression pattern
PBB GE GALR1 220821 at tn.png
More reference expression data
Species Human Mouse
Entrez 2587 14427
Ensembl ENSG00000166573 ENSMUSG00000024553
UniProt P47211 P56479
RefSeq (mRNA) NM_001480 NM_008082
RefSeq (protein) NP_001471 NP_032108
Location (UCSC) Chr 18:
77.25 – 77.28 Mb
Chr 18:
82.39 – 82.41 Mb
PubMed search [1] [2]

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.[1]

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.[1]

See also[edit]


External links[edit]

  • "Galanin Receptors: GAL1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.