Galanin receptor 1

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GALR1
Identifiers
Aliases GALR1, GALNR, GALNR1, Galanin receptor 1
External IDs MGI: 1096364 HomoloGene: 74396 GeneCards: 2587
RNA expression pattern
PBB GE GALR1 220821 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001480

NM_008082

RefSeq (protein)

NP_001471.2

NP_032108.1

Location (UCSC) Chr 18: 77.25 – 77.28 Mb Chr 18: 82.39 – 82.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.[1]

Function[edit]

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.[1]

See also[edit]

References[edit]

Further reading[edit]

  • Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M, Mayaux JF (Oct 1994). "Molecular cloning of a functional human galanin receptor". Proceedings of the National Academy of Sciences of the United States of America 91 (21): 9780–3. doi:10.1073/pnas.91.21.9780. PMC 44900. PMID 7524088. 
  • Walli R, Schäfer H, Morys-Wortmann C, Paetzold G, Nustede R, Schmidt WE (Dec 1994). "Identification and biochemical characterization of the human brain galanin receptor". Journal of Molecular Endocrinology 13 (3): 347–56. doi:10.1677/jme.0.0130347. PMID 7534460. 
  • Kask K, Berthold M, Kahl U, Nordvall G, Bartfai T (Jan 1996). "Delineation of the peptide binding site of the human galanin receptor". The EMBO Journal 15 (2): 236–44. PMC 449938. PMID 8617199. 
  • Lorimer DD, Benya RV (May 1996). "Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract". Biochemical and Biophysical Research Communications 222 (2): 379–85. doi:10.1006/bbrc.1996.0752. PMID 8670213. 
  • Nicholl J, Kofler B, Sutherland GR, Shine J, Iismaa TP (Dec 1995). "Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization". Genomics 30 (3): 629–30. doi:10.1006/geno.1995.1292. PMID 8825658. 
  • Sullivan KA, Shiao LL, Cascieri MA (Apr 1997). "Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors". Biochemical and Biophysical Research Communications 233 (3): 823–8. doi:10.1006/bbrc.1997.6542. PMID 9168941. 
  • Jacoby AS, Webb GC, Liu ML, Kofler B, Hort YJ, Fathi Z, Bottema CD, Shine J, Iismaa TP (Nov 1997). "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene". Genomics 45 (3): 496–508. doi:10.1006/geno.1997.4960. PMID 9367674. 
  • Lorimer DD, Matkowskj K, Benya RV (Dec 1997). "Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R)". Biochemical and Biophysical Research Communications 241 (2): 558–64. doi:10.1006/bbrc.1997.7838. PMID 9425310. 
  • Fitzgerald LW, Patterson JP, Conklin DS, Horlick R, Largent BL (Nov 1998). "Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides". The Journal of Pharmacology and Experimental Therapeutics 287 (2): 448–56. PMID 9808667. 
  • Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D'Silva NJ (Jun 2005). "Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma". The Journal of Biological Chemistry 280 (24): 22564–71. doi:10.1074/jbc.M414589200. PMID 15767248. 
  • Schäuble N, Reichwald K, Grassl W, Bechstein H, Müller HC, Scherag A, Geller F, Utting M, Siegfried W, Goldschmidt H, Blundell J, Lawton C, Alam R, Whybrow S, Stubbs J, Platzer M, Hebebrand J, Hinney A (Jun 2005). "Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity". The Journal of Nutrition 135 (6): 1387–92. PMID 15930442. 
  • Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA (Jul 2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain, and Behavior 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333. 

External links[edit]

  • "Galanin Receptors: GAL1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.