SENP8

SENP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XT9, 2BKQ, 2BKR
Identifiers
Aliases	SENP8, DEN1, NEDP1, PRSC2, SUMO/sentrin peptidase family member, NEDD8 specific, SUMO peptidase family member, NEDD8 specific
External IDs	OMIM: 608659; MGI: 1918849; HomoloGene: 14084; GeneCards: SENP8; OMA:SENP8 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	72,143,692 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	59,657,993 bp
RNA expression pattern
	Top expressed in
	sperm; ; gonad; ; secondary oocyte; ; testicle; ; right testis; ; left testis; ; muscle of thigh; ; islet of Langerhans; ; gastrocnemius muscle; ; ventricular zone;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; lumbar spinal ganglion; ; genital tubercle; ; tail of embryo; ; hand; ; otolith organ; ; facial motor nucleus; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; hydrolase activity; NEDD8-specific protease activity; endopeptidase activity;
Cellular component	cytosol; nucleus;
Biological process	proteolysis; protein deubiquitination; protein desumoylation; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	123228
	71599
	ENSG00000166192
	ENSMUSG00000051705
	Q96LD8
	Q9D2Z4
	NM_001166340; NM_001172109; NM_001172110; NM_001172111; NM_145204
	NM_001172068; NM_001172069; NM_001172070; NM_001172071; NM_027838
	NP_001159812; NP_001165580; NP_001165581; NP_001165582; NP_660205
	NP_001165539; NP_001165540; NP_001165541; NP_001165542; NP_082114
	Wikidata
View/Edit Human	View/Edit Mouse

Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166192 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051705 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT (Jul 2003). "NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins". J Biol Chem. 278 (28): 25637–43. doi:10.1074/jbc.M212948200. PMID 12730221.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Gan-Erdene T, Nagamalleswari K, Yin L, Wu K, Pan ZQ, Wilkinson KD (Jul 2003). "Identification and characterization of DEN1, a deneddylase of the ULP family". J Biol Chem. 278 (31): 28892–900. doi:10.1074/jbc.M302890200. PMID 12759362.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: SENP8 SUMO/sentrin specific peptidase family member 8".

Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS (2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". J. Biol. Chem. 282 (36): 26217–24. doi:10.1074/jbc.M702444200. PMID 17591783.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS (2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family". Biochem. J. 409 (2): 461–9. doi:10.1042/BJ20070940. PMID 17916063.

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This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166192 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051705 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12730221-5] Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT (Jul 2003). "NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins". J Biol Chem. 278 (28): 25637–43. doi:10.1074/jbc.M212948200. PMID 12730221.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid12759362-6] Gan-Erdene T, Nagamalleswari K, Yin L, Wu K, Pan ZQ, Wilkinson KD (Jul 2003). "Identification and characterization of DEN1, a deneddylase of the ULP family". J Biol Chem. 278 (31): 28892–900. doi:10.1074/jbc.M302890200. PMID 12759362.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[entrez-7] "Entrez Gene: SENP8 SUMO/sentrin specific peptidase family member 8".

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