KMT5A

KMT5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZKK, 2BQZ, 3F9W, 3F9X, 3F9Y, 3F9Z, 4IJ8, 5HQ2
Identifiers
Aliases	KMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07
External IDs	OMIM: 607240; MGI: 1915206; HomoloGene: 41372; GeneCards: KMT5A; OMA:KMT5A - orthologs
EC number	2.1.1.354
Gene location (Human)
Chr.	Chromosome 12 (human)
End	123,409,353 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	124,600,371 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right coronary artery; ; thoracic aorta; ; ascending aorta; ; Achilles tendon; ; right lobe of thyroid gland; ; body of pancreas; ; popliteal artery; ; left lobe of thyroid gland; ; left uterine tube;
	Top expressed in
	pyloric antrum; ; lip; ; knee joint; ; yolk sac; ; cumulus cell; ; secondary oocyte; ; lacrimal gland; ; esophagus; ; ascending aorta; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-lysine N-methyltransferase activity; methyltransferase activity; transcription corepressor activity; p53 binding; protein binding; transferase activity; lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity; histone methyltransferase activity (H4-K20 specific);
Cellular component	nucleus; nucleoplasm; chromosome; cytosol;
Biological process	methylation; regulation of transcription, DNA-templated; peptidyl-lysine monomethylation; cell cycle; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; cell division; transcription, DNA-templated; regulation of DNA damage response, signal transduction by p53 class mediator; histone lysine methylation; regulation of signal transduction by p53 class mediator; histone H4-K20 methylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	387893
	67956
	ENSG00000183955
	ENSMUSG00000049327
	Q9NQR1
	Q2YDW7
NM_020382; NM_001324504; NM_001324505; NM_001324506; NM_001367386;
	NM_001367388; NM_001367389
	NM_030241; NM_001310723; NM_001310725; NM_001310727
NP_001311433; NP_001311434; NP_001311435; NP_065115; NP_001354315;
	NP_001354317; NP_001354318
NP_001297652; NP_001297654; NP_001297656; NP_084517; NP_001392317;
	NP_001392319
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-lysine N-methyltransferase SETD8 is an enzyme that in humans is encoded by the SETD8 gene.^[5]^[6]^[7]^[8]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183955 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049327 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Couture JF, Collazo E, Brunzelle JS, Trievel RC (Jun 2005). "Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase". Genes Dev. 19 (12): 1455–65. doi:10.1101/gad.1318405. PMC 1151662. PMID 15933070.
^ Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D (Jun 2002). "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin". Mol Cell. 9 (6): 1201–13. doi:10.1016/S1097-2765(02)00548-8. PMID 12086618.
^ Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y (Jul 2002). "Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase". Curr Biol. 12 (13): 1086–99. doi:10.1016/S0960-9822(02)00924-7. PMID 12121615.
^ "Entrez Gene: SETD8 SET domain containing (lysine methyltransferase) 8".

References

Further reading