SF2 may refer to:
- Fahlin SF-2 Plymocoupe an experimental aircraft built by Ole Fahlin
- SF zwei (Schweizer Fernsehen zwei), a Swiss television channel broadcasting in German
- SoundFont 2, a file format for audio samples and associated data for use in musical synthesis
- ASF/SF2, a protein
- Sulfur difluoride, a chemical compound
- a kind of glass fabricated by Schott.
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