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SF3A2

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SF3A2
Identifiers
AliasesSF3A2, PRP11, PRPF11, SAP62, SF3a66, splicing factor 3a subunit 2
External IDsOMIM: 600796; MGI: 104912; HomoloGene: 136815; GeneCards: SF3A2; OMA:SF3A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007165

NM_013651

RefSeq (protein)

NP_009096

n/a

Location (UCSC)Chr 19: 2.24 – 2.25 MbChr 10: 80.63 – 80.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Splicing factor 3A subunit 2 is a protein that in humans is encoded by the SF3A2 gene.[5][6][7]

Function

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This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.[7]

Interactions

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SF3A2 has been shown to interact with DDX46.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104897Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020211Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bennett M, Reed R (October 1993). "Correspondence between a mammalian spliceosome component and an essential yeast splicing factor". Science. 262 (5130): 105–8. Bibcode:1993Sci...262..105B. doi:10.1126/science.8211113. PMID 8211113.
  6. ^ Dresser DW, Hacker A, Lovell-Badge R, Guerrier D (September 1995). "The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous". Human Molecular Genetics. 4 (9): 1613–8. doi:10.1093/hmg/4.9.1613. PMID 8541848.
  7. ^ a b "Entrez Gene: SF3A2 splicing factor 3a, subunit 2, 66kDa".
  8. ^ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (September 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.

Further reading

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