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Solute carrier family 27 (fatty acid transporter), member 5
External IDs OMIM603314 MGI1347100 HomoloGene7596 ChEMBL: 5196 GeneCards: SLC27A5 Gene
EC number
RNA expression pattern
PBB GE SLC27A5 219733 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10998 26459
Ensembl ENSG00000083807 ENSMUSG00000030382
UniProt Q9Y2P5 Q4LDG0
RefSeq (mRNA) NM_012254 NM_009512
RefSeq (protein) NP_036386 NP_033538
Location (UCSC) Chr 19:
58.48 – 58.51 Mb
Chr 7:
12.99 – 13 Mb
PubMed search [1] [2]

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.[1][2][3]

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.[3]

See also[edit]


  1. ^ Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA (Oct 1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein". Mol Genet Metab 68 (1): 32–42. doi:10.1006/mgme.1999.2883. PMID 10479480. 
  2. ^ Steinberg SJ, Mihalik SJ, Kim DG, Cuebas DA, Watkins PA (Jun 2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J Biol Chem 275 (21): 15605–8. doi:10.1074/jbc.C000015200. PMID 10749848. 
  3. ^ a b "Entrez Gene: SLC27A5 solute carrier family 27 (fatty acid transporter), member 5". 

Further reading[edit]

  • Fisher E, Nitz I, Lindner I et al. (2007). "Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation". Mol Nutr Food Res 51 (2): 185–91. doi:10.1002/mnfr.200600162. PMID 17266179. 
  • Tu N, Hu Y, Mivechi NF (2006). "Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins". J. Cell. Biochem. 98 (6): 1528–42. doi:10.1002/jcb.20865. PMID 16552721. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Mihalik SJ, Steinberg SJ, Pei Z et al. (2002). "Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling". J. Biol. Chem. 277 (27): 24771–9. doi:10.1074/jbc.M203295200. PMID 11980911. 
  • Watkins PA, Pevsner J, Steinberg SJ (2000). "Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein". Prostaglandins Leukot. Essent. Fatty Acids 60 (5–6): 323–8. doi:10.1016/S0952-3278(99)80007-6. PMID 10471116. 
  • Hirsch D, Stahl A, Lodish HF (1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8625–9. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728. 
  • Berger J, Truppe C, Neumann H, Forss-Petter S (1998). "A novel relative of the very-long-chain acyl-CoA synthetase and fatty acid transporter protein genes with a distinct expression pattern". Biochem. Biophys. Res. Commun. 247 (2): 255–60. doi:10.1006/bbrc.1998.8770. PMID 9642112.