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Sugar transporter SWEET1

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(Redirected from SLC50A1)
SLC50A1
Identifiers
AliasesSLC50A1, HsSWEET1, RAG1AP1, SCP, SWEET1, slv, solute carrier family 50 member 1
External IDsOMIM: 613683; MGI: 107417; HomoloGene: 40647; GeneCards: SLC50A1; OMA:SLC50A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009057

RefSeq (protein)

NP_033083

Location (UCSC)Chr 1: 155.14 – 155.14 MbChr 3: 89.18 – 89.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sugar transporter SWEET1, also known as RAG1-activating protein 1 and stromal cell protein (SCP), is a membrane protein that in humans is encoded by the SLC50A1 gene.[5] SWEET1 is the sole transporter from the SLC50 (SWEET) gene family present in the genomes of most animal species, with the exception of the nematode Caenorhabditis elegans, which has seven.[6]

SWEET1 is a broadly-expressed glucose transporter.[6] As the SWEET family has been identified relatively recently, the full range of its functions in animals is not yet clear.[7] However, the bovine SLC50A1 homologue is associated with lactose concentration in milk,[8] and the CiRGA homologue in the sea squirt Ciona intestinalis is essential for tissue differentiation during embryogenesis, especially the development of the notochord.[9] SWEET genes are common in plant genomes, with around twenty paralogues [6] functioning as both sucrose and hexose transporters, and are also associated with pathogen susceptibility.[6][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169241Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027953Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 50 (sugar efflux transporter), member 1".
  6. ^ a b c d Feng L, Frommer WB (2015). "Structure and function of SemiSWEET and SWEET sugar transporters". Trends in Biochemical Sciences. 40 (8): 480–486. doi:10.1016/j.tibs.2015.05.005. PMID 26071195.
  7. ^ Deng D, Yan N (2016). "GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters". Protein Science. 25 (3): 546–558. doi:10.1002/pro.2858. PMC 4815417. PMID 26650681.
  8. ^ Lopdell TJ, Tiplady K, Struchalin M, Johnson TJ, Keehan M, Sherlock R, Couldrey C, Davis SR, Snell RG, Spelman RJ, Littlejohn MD (2017). "DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content". BMC Genomics. 18 (1): 968. doi:10.1186/s12864-017-4320-3. PMC 5731188. PMID 29246110.
  9. ^ Hamada M, Wada S, Kobayashi K, Satoh N (2005). "Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis of the ascidian Ciona intestinalis". Differentiation. 73 (7): 364–376. doi:10.1111/j.1432-0436.2005.00037.x. PMID 16219040.
  10. ^ Wright EM (2013). "Glucose transport families SLC5 and SLC50". Molecular Aspects of Medicine. 34 (2–3): 183–196. doi:10.1016/j.mam.2012.11.002. PMID 23506865.

Further reading

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