SLU7

SLU7
Identifiers
Aliases	SLU7, 9G8, hSlu7, SLU7 homolog, splicing factor
External IDs	OMIM: 605974; MGI: 2385598; HomoloGene: 4690; GeneCards: SLU7; OMA:SLU7 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	160,421,711 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	43,338,808 bp
RNA expression pattern
	Top expressed in
	testicle; ; Achilles tendon; ; colon; ; superior frontal gyrus; ; sural nerve; ; prefrontal cortex; ; islet of Langerhans;
	Top expressed in
	saccule; ; otic vesicle; ; otic placode; ; genital tubercle; ; granulocyte; ; zygote; ; deep cerebellar nuclei; ; facial motor nucleus; ; vestibular sensory epithelium; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	pre-mRNA 3'-splice site binding; second spliceosomal transesterification activity; metal ion binding; protein binding; nucleic acid binding; zinc ion binding;
Cellular component	cytoplasm; nuclear speck; catalytic step 2 spliceosome; membrane; intracellular membrane-bounded organelle; small nuclear ribonucleoprotein complex; spliceosomal complex; nucleus; nucleoplasm; cytosol;
Biological process	cellular response to heat; RNA splicing, via transesterification reactions; mRNA processing; mRNA 3'-splice site recognition; RNA splicing; intracellular protein transport; alternative mRNA splicing, via spliceosome; RNA export from nucleus; mRNA splicing, via spliceosome; mRNA export from nucleus; mRNA 3'-end processing; termination of RNA polymerase II transcription;
	Sources:Amigo / QuickGO
Orthologs
	10569
	193116
	ENSG00000164609
	ENSMUSG00000020409
	O95391
	Q8BHJ9
	NM_006425
	NM_148673; NM_198936
NP_006416; NP_001351446; NP_001351447; NP_001351449; NP_001351450;
	NP_001351451; NP_001351452
	NP_683514; NP_945174
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164609 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020409 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
^ Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.
^ "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

References

Further reading