SMARCA1

SMARCA1
Identifiers
Aliases	SMARCA1, ISWI, NURF140, SNF2L, SNF2L1, SNF2LB, SNF2LT, SWI, SWI2, hSNF2L, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
External IDs	OMIM: 300012; MGI: 1935127; HomoloGene: 55711; GeneCards: SMARCA1; OMA:SMARCA1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	129,523,500 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	46,981,851 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; tibia; ; endothelial cell; ; ventricular zone; ; right adrenal cortex; ; left adrenal cortex; ; parietal pleura; ; seminal vesicula; ; stromal cell of endometrium; ; cartilage tissue;
	Top expressed in
	Gonadal ridge; ; vas deferens; ; fossa; ; efferent ductule; ; internal carotid artery; ; atrium; ; trigeminal ganglion; ; ureter; ; external carotid artery; ; ovary;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ATP-dependent DNA/DNA annealing activity; DNA binding; nucleotide binding; ATP-dependent activity, acting on DNA; helicase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; protein binding; nucleic acid binding; nucleosome binding; hydrolase activity; ATP binding; transcription factor binding; ATPase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	CERF complex; nucleus; nucleoplasm; intracellular membrane-bounded organelle; NURF complex;
Biological process	chromatin remodeling; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription, DNA-templated; brain development; neuron differentiation; chromatin organization; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6594
	93761
	ENSG00000102038
	ENSMUSG00000031099
	P28370
	Q6PGB8
NM_001282874; NM_001282875; NM_003069; NM_139035; NM_001378261;
	NM_001378262; NM_001378263; NM_001378264
	NM_001290708; NM_053123; NM_001358618; NM_001358619
NP_001269803; NP_001269804; NP_003060; NP_001365190; NP_001365191;
	NP_001365192; NP_001365193
	NP_001277637; NP_444353; NP_001345547; NP_001345548
	Wikidata
View/Edit Human	View/Edit Mouse

Probable global transcription activator SNF2L1 is a protein that in humans is encoded by the SMARCA1 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102038 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031099 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okabe I, Bailey LC, Attree O, Srinivasan S, Perkel JM, Laurent BC, Carlson M, Nelson DL, Nussbaum RL (Oct 1992). "Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae". Nucleic Acids Res. 20 (17): 4649–55. doi:10.1093/nar/20.17.4649. PMC 334196. PMID 1408766.
^ Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R (Nov 2003). "Isolation of human NURF: a regulator of Engrailed gene expression". EMBO J. 22 (22): 6089–100. doi:10.1093/emboj/cdg582. PMC 275440. PMID 14609955.
^ "Entrez Gene: SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1".

References

Further reading