SMG7

SMG7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YA0
Identifiers
Aliases	SMG7, C1orf16, EST1C, SGA56M, nonsense mediated mRNA decay factor, SMG7 nonsense mediated mRNA decay factor
External IDs	OMIM: 610964; MGI: 2682334; HomoloGene: 32235; GeneCards: SMG7; OMA:SMG7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	183,598,246 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	152,778,397 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; tendon of biceps brachii; ; right uterine tube; ; right testis; ; left testis; ; islet of Langerhans; ; epithelium of colon; ; ganglionic eminence; ; postcentral gyrus; ; cerebellar cortex;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ascending aorta; ; aortic valve; ; zygote; ; blood; ; hand; ; cumulus cell; ; mesenteric lymph nodes; ; interventricular septum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding; protein binding; telomeric DNA binding; ribonuclease activity; ribonucleoprotein complex binding; telomerase RNA binding;
Cellular component	cytoplasm; intermediate filament cytoskeleton; nucleus; telomerase holoenzyme complex; cytosol;
Biological process	regulation of dephosphorylation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; telomere maintenance via telomerase; regulation of RNA stability; RNA phosphodiester bond hydrolysis; regulation of telomere maintenance via telomerase;
	Sources:Amigo / QuickGO
Orthologs
	9887
	226517
	ENSG00000116698
	ENSMUSG00000042772
	Q92540
	Q5RJH6
NM_001174061; NM_014837; NM_173156; NM_201568; NM_201569;
	NM_001331007; NM_001350219; NM_001350220; NM_001350221; NM_001350222; NM_001375584; NM_001375585
	NM_001005507; NM_001160256; NM_001160257; NM_001359257
NP_001167532; NP_001317936; NP_775179; NP_963862; NP_963863;
	NP_001337148; NP_001337149; NP_001337150; NP_001337151; NP_001362513; NP_001362514
	NP_001005507; NP_001153728; NP_001153729; NP_001346186
	Wikidata
View/Edit Human	View/Edit Mouse

Protein SMG7 is a protein that in humans is encoded by the SMG7 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116698 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042772 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S (Nov 2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Mol Cell. 12 (5): 1187–200. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.
^ Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E (Feb 2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Mol Cell. 17 (4): 537–47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.
^ "Entrez Gene: SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)".

References

Further reading