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SPANXB1

From Wikipedia, the free encyclopedia
SPANXB1
Identifiers
AliasesSPANXB1, B1, CT11.2, SPANX-B, SPANXB, SPANXB2, SPANXF1, SPANXF2, SPANX family member B1
External IDsOMIM: 300669; HomoloGene: 88477; GeneCards: SPANXB1; OMA:SPANXB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032461
NM_145664

n/a

RefSeq (protein)

NP_115850

n/a

Location (UCSC)Chr X: 141 – 141 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

SPANX family member B1 is a protein that in humans is encoded by the SPANXB1 gene. [3]

Function

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Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode deferentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatozoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000227234Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: SPANX family member B1". Retrieved 2018-07-10.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.