SPPL2B

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SPPL2B
Identifiers
Aliases SPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B
External IDs MGI: 1920468 HomoloGene: 10605 GeneCards: SPPL2B
RNA expression pattern
PBB GE SPPL2B 215833 s at fs.png

PBB GE SPPL2B 210693 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077238
NM_152988

NM_175195

RefSeq (protein)

NP_001070706
NP_694533

NP_780404.2
NP_780404

Location (UCSC) Chr 19: 2.33 – 2.35 Mb Chr 10: 80.86 – 80.87 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.[3]

This gene is a member of the signal peptide peptidase-like protease (SPPL) family with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This enzyme localizes to endosomes, lysosomes, and the plasma membrane. This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells.[4][5] Multiple transcript variants encoding different isoforms have been found for this gene.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: SPPL2B signal peptide peptidase-like 2B". 
  4. ^ Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production". Nat. Cell Biol. 8 (8): 843–8. doi:10.1038/ncb1440. PMID 16829952. 
  5. ^ Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b". Nat. Cell Biol. 8 (8): 894–6. doi:10.1038/ncb1450. PMID 16829951. 

Further reading[edit]