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SR22 or SR-22 may refer to:
- SR-22 (insurance), an official liability insurance document required in some US states
- Cirrus SR22, a type of general aviation light aircraft
- State Route 22, which may be any one of many highways numbered 22
- Ruger SR22, a 22 caliber pistol
- Ruger SR-22, a 22 caliber rifle
| disambiguation page lists articles associated with the same title formed as a letter-number combination.
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