STAG3 (gene)

STAG3
Identifiers
Aliases	STAG3, stromal antigen 3, SPGF61
External IDs	OMIM: 608489; MGI: 1355311; HomoloGene: 40844; GeneCards: STAG3; OMA:STAG3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,221,488 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	138,310,655 bp
RNA expression pattern
	Top expressed in
	oocyte; ; right testis; ; left testis; ; secondary oocyte; ; right uterine tube; ; right hemisphere of cerebellum; ; C1 segment; ; gonad; ; gastrocnemius muscle; ; body of pancreas;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; Gonadal ridge; ; morula; ; embryo; ; blastocyst; ; zygote; ; embryo; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	chromatin binding; protein binding;
Cellular component	synaptonemal complex; meiotic cohesin complex; chromosome, centromeric region; nucleus; chromosome; extracellular space; chromatin; cohesin complex;
Biological process	cell cycle; meiosis; synaptonemal complex assembly; chromosome segregation; sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	10734
	50878
	ENSG00000066923
	ENSMUSG00000036928
	Q9UJ98
	O70576
	NM_001282716; NM_001282717; NM_001282718; NM_012447; NM_001375438
	NM_016964
	NP_001269645; NP_001269646; NP_001269647; NP_036579; NP_001362367
	NP_058660
	Wikidata
View/Edit Human	View/Edit Mouse

Stromal antigen 3 is a protein that in humans is encoded by the STAG3 gene.^[5]

A homozygous 1-bp deletion inducing a frameshift mutation in STAG3 causes premature ovarian failure.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000066923 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036928 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Stromal antigen 3". Retrieved 2013-12-04.
^ Caburet, Sandrine; Arboleda, Valerie A.; Llano, Elena; Overbeek, Paul A.; Barbero, Jose Luis; Oka, Kazuhiro; Harrison, Wilbur; Vaiman, Daniel; Ben-Neriah, Ziva; García-Tuñón, Ignacio; Fellous, Marc; Pendás, Alberto M.; Veitia, Reiner A.; Vilain, Eric (2014). "Mutant Cohesin in Premature Ovarian Failure". New England Journal of Medicine. 370 (10): 943–949. doi:10.1056/NEJMoa1309635. ISSN 0028-4793.

Quaye, L.; Dafou, D.; Ramus, S. J.; Song, H.; Gentry-Maharaj, A. G.; Notaridou, M.; Hogdall, E.; Kjaer, S. K.; Christensen, L.; Hogdall, C.; Easton, D. F.; Jacobs, I.; Menon, U.; Pharoah, P. D. P.; Gayther, S. A. (2009). "Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival". Human Molecular Genetics. 18 (10): 1869–1878. doi:10.1093/hmg/ddp107. PMID 19270026.
Pezzi, N.; Prieto, I.; Kremer, L.; Pérez Jurado, L. A.; Valero, C.; Del Mazo, J.; Martínez-a, C.; Barbero, J. L. (2000). "STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion". FASEB Journal. 14 (3): 581–592. PMID 10698974.
Prieto, I.; Suja, J. A.; Pezzi, N.; Kremer, L.; Martínez-a, C.; Rufas, J. S.; Barbero, J. L. (2001). "Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I". Nature Cell Biology. 3 (8): 761–766. doi:10.1038/35087082. PMID 11483963.
Notaridou, M.; Quaye, L.; Dafou, D.; Jones, C.; Song, H.; Høgdall, E.; Kjaer, S. K.; Christensen, L.; Høgdall, C.; Blaakaer, J.; McGuire, V.; Wu, A. H.; Van Den Berg, D. J.; Pike, M. C.; Gentry-Maharaj, A.; Wozniak, E.; Sher, T.; Jacobs, I. J.; Tyrer, J.; Schildkraut, J. M.; Moorman, P. G.; Iversen, E. S.; Jakubowska, A.; Mędrek, K.; Lubiński, J.; Ness, R. B.; Moysich, K. B.; Lurie, G.; Wilkens, L. R.; Carney, M. E. (2011). "Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer". International Journal of Cancer. 128 (9): 2063–2074. doi:10.1002/ijc.25554. PMC 3098608. PMID 20635389.
Prieto, I.; Pezzi, N.; Buesa, J. M.; Kremer, L.; Barthelemy, I.; Carreiro, C.; Roncal, F.; Martinez, A.; Gomez, L.; Fernandez, R. L.; Martinez-a, C.; Barbero, J. L. (2002). "STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis". EMBO Reports. 3 (6): 543–550. doi:10.1093/embo-reports/kvf108. PMC 1084142. PMID 12034751.
Barber, T. D.; McManus, K.; Yuen, K. W. Y.; Reis, M.; Parmigiani, G.; Shen, D.; Barrett, I.; Nouhi, Y.; Spencer, F.; Markowitz, S.; Velculescu, V. E.; Kinzler, K. W.; Vogelstein, B.; Lengauer, C.; Hieter, P. (2008). "Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers". Proceedings of the National Academy of Sciences. 105 (9): 3443–3448. doi:10.1073/pnas.0712384105. PMC 2265152. PMID 18299561.
Maeshima, K.; Yoshida, K.; Shirahige, K. (2008). "Function of cohesin in transcription". Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 53 (11): 1337–1344. PMID 18788457.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000066923 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036928 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Stromal antigen 3". Retrieved 2013-12-04.

[CaburetArboleda2014-6] Caburet, Sandrine; Arboleda, Valerie A.; Llano, Elena; Overbeek, Paul A.; Barbero, Jose Luis; Oka, Kazuhiro; Harrison, Wilbur; Vaiman, Daniel; Ben-Neriah, Ziva; García-Tuñón, Ignacio; Fellous, Marc; Pendás, Alberto M.; Veitia, Reiner A.; Vilain, Eric (2014). "Mutant Cohesin in Premature Ovarian Failure". New England Journal of Medicine. 370 (10): 943–949. doi:10.1056/NEJMoa1309635. ISSN 0028-4793.

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References

Further reading