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Samuel Barry Guze (October 18, 1923 – July 19, 2000) was an American psychiatrist, medical educator, and researcher. He was an influential psychiatrist and worked at the Washington University School of Medicine in St. Louis for most of his career.
Along with Eli Robins, George Winokur and others, Guze advanced psychiatry by establishing criteria for diagnosis. A short paper by Guze and Robins contained a discussion of validity from a medical perspective. and came up with five phases of research that demonstrated that a diagnostic concept represented a disease. These five phases were: clinical description, laboratory studies, delimitation from other disorders, follow-up studies and family studies. While previously two psychiatrists might interview the same patient and propose differing diagnoses, the Guze system lead to great leaps in diagnostic "reliability", that is, different physicians would agree more often on what the diagnosis really was. Following publication of what came to be known as the Feighner Criteria, in 1980 he helped compile Diagnostic and Statistical Manual for Mental Disorders (3rd edition). The diagnostic reliability is still an essential component to modern versions of the Manual.
He was also among the first psychiatrists to study twins as a way to investigate the role of heredity in mental illness and contributed to the knowledge of genetic vulnerability to alcoholism and schizophrenia.
Feighner, JP, Robins, E, Guze, SB, Woodruff, RA Jr, Winokur, G, Munoz, R. Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 1972; 26:57-63
Robins, E and Guze, SB. Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. Am J Psychiatry 1970; 126:983-987
- "Establishment of Diagnostic Validity in Psychiatric Illness: Its Application to Schizophrenia, Robins and Guze 1970". Am J Psychiatry 126:983-987, January 1970.
- "Famed psychiatrist Samuel Guze dies". Washington University in St. Louis.
- Fatemi, S. Hossein; Clayton, Paula J. (2008). The medical basis of psychiatry. Humana Press. ISBN 978-1-58829-917-8.
- Ghaemi, S. Nassir (2010). The rise and fall of the biopsychosocial model:reconciling art and science in psychiatry. JHU Press. ISBN 978-0-8018-9390-2.
- Blaney, Paul; Millon, Theodore (2009). Oxford Textbook of Psychopathology. Oxford University Press. ISBN 978-0-19-988836-8.
- Saxon, Wolfgang (2000-07-22). "Samuel Guze, 76, Psychiatrist Who Pushed Link to Medicine". The New York Times. Retrieved 2011-12-28.
- Fatemi; Clayton, p.738
- Ghaemi, p.70
- Oxford Uni
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