She is an ex-wife of actor Keith Carradine. They wed February 6, 1982, and had two children: Cade Richmond Carradine, born on July 19, 1982, and Sorel Johannah Carradine, born on June 18, 1985. They separated in 1993, and filed for divorce in 1999.
Sandra Will Carradine has been active for a number of years with the Telluride Film Festival. In 1991, she left California and founded the "Sheridan Arts Foundation" to save and restore the historic Sheridan Opera House in Telluride, Colorado On April 1, 1994, she was involved in a Telluride heli-skiing company helicopter crash along with son, Colorado real estate mogul Ricky Taubman, and supermodel/actress Christie Brinkley.