Saos-2 cells

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Saos-2 ("Sarcoma osteogenic") is a cell line derived from the primary osteosarcoma of an 11-year-old Caucasian girl in 1973 by Fogh et al.[1]

In 1987 Rodan et al. determined that Saos-2 cells "possess several osteoblastic features and could be useful as a permanent line of human osteoblast-like cells and as a source of bone-related molecules."[2]

Besides their worldwide availability, some of the advantages for using Saos-2 cell line are that they have well-documented characterization data, the possibility to obtain large amounts of cells in short time, and the fact that Saos-2 cells can be fully differentiated in a manner that the osteoblastic cells naturally do.[3] The latter point is described particularly as "the ability of Saos-2 cells to deposit a mineralization-competent extracellular matrix",[4] which makes these cells a valuable model for studying events associated with the late osteoblastic differentiation stage in human cells.[5]


  1. ^ Fogh J, Fogh JM, Orfeo T (1977). "One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice". J Natl Cancer Inst. 59 (1): 221–226. PMID 327080. 
  2. ^ Rodan SB, Imai Y, Thiede MA, Wesolowski G, Thompson D, Bar-Shavit Z, Shull S, Mann K, Rodan GA (1987). "Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties". Cancer Res. 47 (18): 4961–6. PMID 3040234. 
  3. ^ Hausser HJ, Brenner RE (2005). "Phenotypic instability of Saos-2 cells in long-term culture". Biochem. Biophys. Res. Commun. 333 (1): 216–22. doi:10.1016/j.bbrc.2005.05.097. PMID 15939397. 
  4. ^ McQuillan DJ, Richardson MD, Bateman JF (1995). "Matrix deposition by a calcifying human osteogenic sarcoma cell line (SAOS- 2)". Bone. 16 (4): 415–26. doi:10.1016/8756-3282(95)90186-8. PMID 7605701. 
  5. ^ Gundle R, Beresford JN (1995). "The isolation and culture of cells from explants of human trabecular bone". Calcif. Tissue Int. 56 (Suppl 1): S8-10. PMID 7719993. 

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