Selenoprotein O

SELENOO
Identifiers
Aliases	SELENOO, selenoprotein O, SELO
External IDs	OMIM: 607917; MGI: 1919007; HomoloGene: 69439; GeneCards: SELENOO; OMA:SELENOO - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.33 Start 50,201,011 bp End 50,217,616 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E3 Start 88,973,287 bp End 88,984,543 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right lobe of liver right hemisphere of cerebellum cardia granulocyte mucosa of ileum mucosa of transverse colon apex of heart thymus skin of leg Top expressed in left lobe of liver right kidney spermatocyte proximal tubule granulocyte lacrimal gland otolith organ utricle submandibular gland human kidney More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ATP binding transferase activity nucleotidyltransferase activity metal ion binding protein adenylyltransferase activity Cellular component mitochondrion Biological process protein adenylylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83642 223776 Ensembl ENSG00000073169 ENSMUSG00000035757 UniProt Q9BVL4 Q9DBC0 RefSeq (mRNA) NM_031454 NM_027905 RefSeq (protein) NP_113642 NP_082181 Location (UCSC) Chr 22: 50.2 – 50.22 Mb Chr 15: 88.97 – 88.98 Mb PubMed search
Wikidata
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Selenoprotein O is a protein that in humans is encoded by the SELENOO gene.

Function

This gene encodes a selenoprotein, pseudokinase selenoprotein-O(SelO), that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The SELO protein AMPylates proteins involved in redox homeostasis. As a result this selenoprotein is thought to be necessary for the cellular response to oxidative stress.

Further reading

• Mabuchi H, Tatami R, Ueda K, Ueda R, Haba T, Kametani T, Watanabe A, Wakasugi T, Ito S, Koizumi J, Ohta M, Miyamoto S, Takeda R (April 1979). "Serum lipid and lipoprotein levels in Japanese patients with familial hypercholesterolemia". Atherosclerosis. 32 (4): 435–44. doi:10.1016/0021-9150(79)90009-1. PMID 223596.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.