Shaodong Guo

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Shaodong Guo
Born (1968-08-10) August 10, 1968 (age 55)
CitizenshipAmerican
Alma materHuazhong Agricultural University, China (BS, MS)
Peking University, Beijing, China (Ph.D.)
Occupation(s)Nutrition scientist, academic and diabetes researcher
Known forNutrient sensing and gene transcriptional regulation of blood glucose and diabetes mechanisms
Scientific career
FieldsDiabetes and its complication and prevention
InstitutionsUniversity of Illinois at Chicago
Harvard Medical School
Texas A&M University

Shaodong Guo (Chinese: 郭绍东; born on 10 August 1968) is a Chinese-American nutrition scientist, academic, and diabetes researcher. He is a professor in nutrition and medicine at the Department of Nutrition of Texas A&M University.[1] He has been a senior editor for Journal of Endocrinology and Journal of Molecular Endocrinology.

Biography[edit]

Guo graduated from Enshi high school and attended Huazhong Agricultural University in Wuhan, obtaining a bachelor's degree in agronomy and a master's degree in biochemistry in 1989. He then graduated from Peking University (PKU) in 1995 with a Ph.D. in physiology and molecular biology. Followed by a decade of high education in China, Guo went to U.S.A. in 1997, joining the University of Illinois at Chicago (UIC) and then Harvard Medical School for a decade of medical research and training. Guo was a faculty as instructor in medicine in Children's Hospital Boston and Harvard University prior to joining the faculty of Texas A&M University in 2009.[1]

Much of Guo's research centers on insulin signaling, insulin resistance, type 2 diabetes mellitus and its complications. Following the completion of Ph.D. with his mentor Xiangyu Wu in PKU, Guo had three postdoctoral appointments. The first was at the Institute of Genetics and Developmental Biology of Chinese Academic of Sciences from 1995 to 1997 with Fangzhen Sun majored in studies of genetics and developmental biology. Next, he went to the UIC to work with Terry Unterman, M.D. in study of insulin from 1997 to 2001. He joined Harvard Medical School to work with William Aird, Victor J Dzau, and Morris F. White in studies of cardiovascular biology and diabetes mellitus from 2001 to 2008. He was hired at Texas A&M University as an assistant professor in the department of medicine in 2009 and was appointed to associate professor in 2015. In 2016, he joined the department of nutrition.[2][3]

Guo has made several fundamental discoveries by identifying new pathways in the field of insulin and type 2 diabetes mellitus. These discoveries include identification of key roles of a nutritional and hormonal sensor – forkhead/winged helix transcription factor Foxo1 that mediates the action of insulin,[4] glucagon,[5] estrogen,[6][7] bioactive functional foods,[8] and anti-diabetic drug metformin[9] in control of nutrient and tissue homeostasis, which has a significant impact on precision nutrition and medicine through the seminar research in diabetes and genetics.[10] Moreover, Guo's lab has demonstrated a crucial mechanism of diabetes-induced heart failure by establishing the critical role of insulin and suppressed-Foxo1 via the insulin receptor substrate (IRS) proteins in control of cardiac structure and function.[11][12] Taken together, Guo's research projects highlight the importance of nutrient sensing and hormonal signaling in the regulation of gene transcription via the Foxo1 that controls not only blood glucose but also the cardiovascular structure, function and beyond.[13]

Guo has authored over 108 publications, has been cited more than 8,000 times, and has a Google Scholar Citation H-index of 38.[14]

Guo was book chapter writer and editor-in-chief for the textbook Metabolic Syndrome (Springer Reference, 2016) and Nutrition and Metabolic Disease (Marsland, 2018).

Awards and honors[edit]

  • 2007 - Junior Faculty Award, American Diabetes Association
  • 2015 - Career Development Award, American Diabetes Association
  • 2015 - Research Excellence Thomas R Lee Award, American Diabetes Association[15]
  • 2020 - Distinguished Reviewer Award, American Diabetes Association
  • 2021 - Presidential Impact Fellow of Texas A&M University[16][17]

References[edit]

  1. ^ a b "Shaodong Guo - Texas A&M University".
  2. ^ "Shaodong Guo - Allied Academies".
  3. ^ "Guo, Shaodong".
  4. ^ Cheng, Zhiyong; Guo, Shaodong; Copps, Kyle; Dong, Xiaochen; Kollipara, Ramya; Rodgers, Joseph T.; Depinho, Ronald A.; Puigserver, Pere; White, Morris F. (2009). "Foxo1 integrates insulin signaling with mitochondrial function in the liver". Nature Medicine. 15 (11): 1307–1311. doi:10.1038/nm.2049. PMC 3994712. PMID 19838201.
  5. ^ Wu, Y.; Pan, Q.; Yan, H.; Zhang, K.; Guo, X.; Xu, Z.; Yang, W.; Qi, Y.; Guo, C. A.; Hornsby, C.; Zhang, L.; Zhou, A.; Li, L.; Chen, Y.; Zhang, W.; Sun, Y.; Zheng, H.; Wondisford, F.; He, L.; Guo, S. (2018). "Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis". Diabetes. 67 (11): 2167–2182. doi:10.2337/db18-0674. PMC 6198346. PMID 30201683.
  6. ^ Yan, H.; Yang, W.; Zhou, F.; Li, X.; Pan, Q.; Shen, Z.; Han, G.; Newell-Fugate, A.; Tian, Y.; Majeti, R.; Liu, W.; Xu, Y.; Wu, C.; Allred, K.; Allred, C.; Sun, Y.; Guo, S. (2019). "Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1". Diabetes. 68 (2): 291–304. doi:10.2337/db18-0638. PMC 6341301. PMID 30487265.
  7. ^ Liao, Wang; Yang, Wanbao; Shen, Zheng; Ai, Weiqi; Pan, Quan; Sun, Yuxiang; Guo, Shaodong (2021). "Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis". Diabetes. 70 (3): 696–709. doi:10.2337/db20-0954. PMC 7897351. PMID 33408127.
  8. ^ Liu, H.; Liu, M.; Jin, Z.; Yaqoob, S.; Zheng, M.; Cai, D.; Liu, J.; Guo, S. (2019). "Ginsenoside Rg2 inhibits adipogenesis in 3T3-L1 preadipocytes and suppresses obesity in high-fat-diet-induced obese mice through the AMPK pathway". Food & Function. 10 (6): 3603–3614. doi:10.1039/c9fo00027e. PMID 31161181. S2CID 174808850.
  9. ^ Guo, Xiaoqin; Li, Xiaopeng; Yang, Wanbao; Liao, Wang; Shen, James Zheng; Ai, Weiqi; Pan, Quan; Sun, Yuxiang; Zhang, Kebin; Zhang, Rui; Qiu, Yuyang; Dai, Qian; Zheng, Hongting; Guo, Shaodong (2021). "Metformin Targets Foxo1 to Control Glucose Homeostasis". Biomolecules. 11 (6): 873. doi:10.3390/biom11060873. PMC 8231152. PMID 34208360.
  10. ^ "Researchers zero in on potential therapeutic target for diabetes, associated diseases". 13 December 2018.
  11. ^ Qi, Y.; Xu, Z.; Zhu, Q.; Thomas, C.; Kumar, R.; Feng, H.; Dostal, D. E.; White, M. F.; Baker, K. M.; Guo, S. (2013). "Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance". Diabetes. 62 (11): 3887–4700. doi:10.2337/db13-0095. PMC 3806607. PMID 24159000.
  12. ^ Guo, C. A.; Guo, S. (2017). "Insulin receptor substrate signaling controls cardiac energy metabolism and heart failure". The Journal of Endocrinology. 233 (3): R131–R143. doi:10.1530/JOE-16-0679. PMC 9675292. PMID 28381504.
  13. ^ Qi, Y.; Zhang, K.; Wu, Y.; Xu, Z.; Yong, Q.; Kumar, R.; Baker, K. M.; Zhu, Q.; Chen, S.; Guo, S. (2014). "Novel Mechanism of Blood Pressure Regulation By Foxo1-Mediated Transcriptional Control of Hepatic Angiotensinogen". Hypertension. 64 (5): 1131–1140. doi:10.1161/HYPERTENSIONAHA.114.03970. PMC 4192068. PMID 25069665.
  14. ^ "Shaodong Guo - Google Scholar".
  15. ^ "DiabetesPro Quarterly".
  16. ^ "Texas A&M University Announces 2021 Presidential Impact Fellows".
  17. ^ "2021 Presidential Impact Fellows named by Texas A&M". 28 October 2021.
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