Somatotropin family

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Somatotropin hormone family

The Somatotropin family is a protein family whose titular representative is somatotropin, also known as growth hormone, a hormone that plays an important role in growth control.[1] Other members include choriomammotropin (lactogen), its placental analogue;[2] prolactin, which promotes lactation in the mammary gland, and placental prolactin-related proteins;[3] proliferin and proliferin related protein;[4] and somatolactin from various fishes.[5][6] The 3D structure of bovine somatotropin has been predicted using a combination of heuristics and energy minimisation.[7]

Human peptides from this family[edit]

CSH1; CSH2; CSHL1; GH1; GH2 (hGH-V); PRL;


  1. ^ Wallis M (1981). "The molecular evolution of pituitary growth-hormone prolactin and placental-lactogen - a protein family showing variable rates of evolution". J. Mol. Evol. 17: 10–18. doi:10.1007/bf01792419. S2CID 19939571.
  2. ^ Kessler MA, Milosavljevic M, Zieler CG, Schuler LA (1989). "A subfamily of bovine prolactin-related transcripts distinct from placental lactogen in the fetal placenta". Biochemistry. 28 (12): 5154–5161. doi:10.1021/bi00438a036. PMID 2765528.
  3. ^ Rand-Weaver M, Noso T, Muramoto K, Kawauchi H (1991). "Isolation and characterization of somatolactin, a new protein related to growth hormone and prolactin from Atlantic cod (Gadus morhua) pituitary glands". Biochemistry. 30 (6): 1509–1515. doi:10.1021/bi00220a010. PMID 1993170.
  4. ^ Connor AM, Waterhouse P, Khokha R, Denhardt DT (1989). "Characterization of a mouse mitogen-regulated protein/proliferin gene and its promoter: a member of the growth hormone/prolactin gene superfamily". Biochim. Biophys. Acta. 1009 (1): 75–82. doi:10.1016/0167-4781(89)90081-X. PMID 2790033.
  5. ^ Benedet S, Björnsson BT, Taranger GL, Andersson E (2008). "Cloning of somatolactin alpha, beta forms and the somatolactin receptor in Atlantic salmon: seasonal expression profile in pituitary and ovary of maturing female broodstock". Reprod. Biol. Endocrinol. 6: 42. doi:10.1186/1477-7827-6-42. PMC 2553077. PMID 18793397.
  6. ^ Benedet Perea, Susana (2008). Growth hormone and somatolactin function during sexual maturation of female Atlantic salmon. (Ph.D.) Department of Zoology/Zoophysiology, Göteborg University, Box 463, SE-405 30 Göteborg, Sweden
  7. ^ Carlacci L, Chou KC, Maggiora GM (1991). "A heuristic approach to predicting the tertiary structure of bovine somatotropin". Biochemistry. 30 (18): 4389–4398. doi:10.1021/bi00232a004. PMID 2021631.
This article incorporates text from the public domain Pfam and InterPro: IPR001400