The highway begins at the US 76/123/SC 28 concurrency west of downtown Clemson. From there, it goes east on Pendleton Road and Old Greenville Highway past Clemson University and into downtown. After exiting the city, it has two interchanges - one with US 76/SC 28 and one with US 123. It then runs through Central to Norris, where it meets South Carolina Highway 137. From Norris, the road continues northeast into Liberty. In downtown Liberty, SC 93 intersects US 178. After leaving Liberty, the highway continues toward Easley. As it enters Easley on Liberty Drive, it promptly meets South Carolina Highway 8, after which it enters downtown on West Main Street. Here, it intersects with South Carolina Highway 135 and becomes East Main Street. After leaving downtown, SC 93 meets US 123 one last time, where its northern terminus lies.
South Carolina 93 is the original alignment of US Highway 123 from Clemson to Easley. When US 123 was given a bypass to the south of Easley in 1958, it was US 123 Business. Between 1962 and 1964, a new freeway was built to carry US 123 from Easley to Clemson. When this was finished, all of former US 123 from Easley to Clemson was renumbered as today's SC 93.