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Sperm protein associated with the nucleus, X-linked, family member A1

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SPANXA1
Identifiers
AliasesSPANXA1, CT11.1, NAP-X, SPAN-X, SPAN-Xa, SPAN-Xb, SPANX, SPANX-A, Sperm protein associated with the nucleus, X-linked, family member A1, CT11.3
External IDsOMIM: 300305; HomoloGene: 88477; GeneCards: SPANXA1; OMA:SPANXA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013453

n/a

RefSeq (protein)

NP_038481

n/a

Location (UCSC)Chr X: 141.58 – 141.59 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Sperm protein associated with the nucleus on the X chromosome A is a protein that in humans is encoded by the SPANXA1 gene.[3][4]

"Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa [sic] while attempting to further define its role in spermatogenesis."[4]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198021Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Westbrook VA, Diekman AB, Klotz KL, Khole VV, von Kap-Herr C, Golden WL, Eddy RL, Shows TB, Stoler MH, Lee CY, Flickinger CJ, Herr JC (Oct 2000). "Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa". Biol Reprod. 63 (2): 469–81. doi:10.1093/biolreprod/63.2.469. PMID 10906052.
  4. ^ a b "Entrez Gene: SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1".

Further reading

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