Stanley Fields (biologist)

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Stan Fields
Born
Stanley Fields
Alma materUniversity of Cambridge
Known forTwo-hybrid screening
Scientific career
Institutions
ThesisSequence analysis of influenza virus RNA (1981)
Website

Stanley Fields is an American biologist best known for developing the yeast two hybrid method for identifying protein–protein interactions.[1] He is currently a professor of Genome Sciences at the University of Washington and Howard Hughes Medical Institute Investigator.[2][3]

Education[edit]

Fields was educated at the University of Cambridge where he was awarded a Doctor of Philosophy in 1981 for research carried out in the Laboratory of Molecular Biology (LMB) with Greg Winter and George Brownlee.[4][5]

Research[edit]

Along with Matt Kaeberlein and Brian Kennedy, Fields has carried out genome-wide screens for aging genes in yeast. Kaeberlein and co-workers have questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins.[6] Instead Kaeberlein, Fields, and Kennedy have proposed that caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase.[7]

Honors and awards[edit]

References[edit]

  1. ^ Fields, S.; Song, O. (1989). "A novel genetic system to detect protein-protein interactions". Nature. 340 (6230): 245–246. Bibcode:1989Natur.340..245F. doi:10.1038/340245a0. PMID 2547163.
  2. ^ Fields, Stanley (2014). "Would Fred Sanger Get Funded Today?". Genetics. 197 (2): 435–439. doi:10.1534/genetics.114.165134. PMC 4063904. PMID 24939989.
  3. ^ Stanley Fields's publications indexed by the Scopus bibliographic database. (subscription required)
  4. ^ Winter, G.; Fields, S.; Brownlee, G. G. (1981). "Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype". Nature. 292 (5818): 72. Bibcode:1981Natur.292...72W. doi:10.1038/292072a0. PMID 7278968.
  5. ^ Fields, S.; Winter, G.; Brownlee, G. G. (1981). "Structure of the neuraminidase gene in human influenza virus A/PR/8/34". Nature. 290 (5803): 213. Bibcode:1981Natur.290..213F. doi:10.1038/290213a0. PMID 7010182.
  6. ^ Kaeberlein, M.; Kirkland, K. T.; Fields, S.; Kennedy, B. K. (2004). "Sir2-Independent Life Span Extension by Calorie Restriction in Yeast". PLoS Biology. 2 (9): e296. doi:10.1371/journal.pbio.0020296. PMC 514491. PMID 15328540.
  7. ^ Kaeberlein, M; Powers Rw, 3rd; Steffen, K. K.; Westman, E. A.; Hu, D; Dang, N; Kerr, E. O.; Kirkland, K. T.; Fields, S; Kennedy, B. K. (2005). "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients". Science. 310 (5751): 1193–6. Bibcode:2005Sci...310.1193K. doi:10.1126/science.1115535. PMID 16293764.
  8. ^ http://www.brandeis.edu/rosenstiel/gabbayaward/past.html