Stanley Fields (biologist)

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Stan Fields
Stanley Fields
Alma materUniversity of Cambridge
Known forTwo-hybrid screening
Scientific career
ThesisSequence analysis of influenza virus RNA (1981)

Stanley Fields is an American biologist best known for developing the yeast two hybrid method for identifying protein–protein interactions.[1] He is currently a professor of Genome Sciences at the University of Washington and Howard Hughes Medical Institute Investigator.[2][3]


Fields was educated at the University of Cambridge where he was awarded a Doctor of Philosophy in 1981 for research carried out in the Laboratory of Molecular Biology (LMB) with Greg Winter and George Brownlee.[4][5]


Along with Matt Kaeberlein and Brian Kennedy, Fields has carried out genome-wide screens for aging genes in yeast. Kaeberlein and co-workers have questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins.[6] Instead Kaeberlein, Fields, and Kennedy have proposed that caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase.[7]

Honors and awards[edit]


  1. ^ Fields, S.; Song, O. (1989). "A novel genetic system to detect protein-protein interactions". Nature. 340 (6230): 245–246. Bibcode:1989Natur.340..245F. doi:10.1038/340245a0. PMID 2547163.
  2. ^ Fields, Stanley (2014). "Would Fred Sanger Get Funded Today?". Genetics. 197 (2): 435–439. doi:10.1534/genetics.114.165134. PMC 4063904. PMID 24939989.
  3. ^ Stanley Fields's publications indexed by the Scopus bibliographic database. (subscription required)
  4. ^ Winter, G.; Fields, S.; Brownlee, G. G. (1981). "Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype". Nature. 292 (5818): 72. Bibcode:1981Natur.292...72W. doi:10.1038/292072a0. PMID 7278968.
  5. ^ Fields, S.; Winter, G.; Brownlee, G. G. (1981). "Structure of the neuraminidase gene in human influenza virus A/PR/8/34". Nature. 290 (5803): 213. Bibcode:1981Natur.290..213F. doi:10.1038/290213a0. PMID 7010182.
  6. ^ Kaeberlein, M.; Kirkland, K. T.; Fields, S.; Kennedy, B. K. (2004). "Sir2-Independent Life Span Extension by Calorie Restriction in Yeast". PLoS Biology. 2 (9): e296. doi:10.1371/journal.pbio.0020296. PMC 514491. PMID 15328540.
  7. ^ Kaeberlein, M; Powers Rw, 3rd; Steffen, K. K.; Westman, E. A.; Hu, D; Dang, N; Kerr, E. O.; Kirkland, K. T.; Fields, S; Kennedy, B. K. (2005). "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients". Science. 310 (5751): 1193–6. Bibcode:2005Sci...310.1193K. doi:10.1126/science.1115535. PMID 16293764.
  8. ^