Surfactant protein D

SFTPD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B08, 1M7L, 1PW9, 1PWB, 2GGU, 2GGX, 2ORJ, 2ORK, 2OS9, 2RIA, 2RIB, 2RIC, 2RID, 2RIE, 3DBZ, 3G81, 3G83, 3G84, 3IKN, 3IKP, 3IKQ, 3IKR, 4E52, 4M17, 4M18
Identifiers
Aliases	SFTPD, COLEC7, PSP-D, SFTP4, SP-D, surfactant protein D
External IDs	OMIM: 178635 MGI: 109515 HomoloGene: 2272 GeneCards: SFTPD
Gene location (Human)
Chr.	Chromosome 10 (human)
End	79,982,614 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	40,907,106 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; visceral pleura; ; upper lobe of lung; ; upper lobe of left lung; ; right lung; ; germinal epithelium; ; body of pancreas; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; skin of abdomen;
	Top expressed in
	right lung; ; right lung lobe; ; left lung; ; left lung lobe; ; lacrimal gland; ; trachea; ; olfactory epithelium; ; parotid gland; ; uterus; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; carbohydrate binding; identical protein binding; lipopolysaccharide binding; monosaccharide binding;
Cellular component	cytoplasm; collagen; endoplasmic reticulum membrane; clathrin-coated endocytic vesicle; endocytic vesicle; extracellular region; lysosome; extracellular space; multivesicular body; rough endoplasmic reticulum;
Biological process	surfactant homeostasis; positive regulation of phagocytosis; immune system process; receptor-mediated endocytosis; respiratory gaseous exchange by respiratory system; reactive oxygen species metabolic process; regulation of cytokine production; negative regulation of T cell proliferation; macrophage chemotaxis; defense response to bacterium; regulation of immune response; lung alveolus development; innate immune response; toll-like receptor signaling pathway; induction of bacterial agglutination; regulation of adhesion of symbiont to host epithelial cell; developmental process;
	Sources:Amigo / QuickGO
Orthologs
	6441
	20390
	ENSG00000133661
	ENSMUSG00000021795
	P35247
	P50404
	NM_003019
	NM_009160
	NP_003010
	NP_033186
	Wikidata
View/Edit Human	View/Edit Mouse

Surfactant protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene.^[5]^[6]

SFTPD is an innate immune system collectin.^[7]^[8]

Interactions

Surfactant protein D has been shown to interact with DMBT1,^[9]^[10] and hemagglutinin of influenza A virus.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133661 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021795 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
^ Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284.
^ "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D".
^ Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). "Surfactant protein D alters allergic lung responses in mice and human subjects". J. Allergy Clin. Immunol. 121 (5): 1140–1147.e2. doi:10.1016/j.jaci.2008.02.011. PMC 4145593. PMID 18355911.
^ Tino MJ, Wright JR (April 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009.
^ Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (May 1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Goh, Boon Chong; Rynkiewicz, Michael J.; Cafarella, Tanya R.; White, Mitchell R.; Hartshorn, Kevan L.; Allen, Kimberly; Crouch, Erika C.; Calin, Oliviana; Seeberger, Peter H. (2013-11-13). "Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation". Biochemistry. 52 (47): 8527–8538. doi:10.1021/bi4010683. PMC 3927399. PMID 24224757.

External links

Surfactant+Protein+D at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Hansen S, Holmskov U (1998). "Structural aspects of collectins and receptors for collectins". Immunobiology. 199 (2): 165–89. doi:10.1016/s0171-2985(98)80025-9. PMID 9777404.
Lu J, Willis AC, Reid KB (1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284.
Persson AV, Gibbons BJ, Shoemaker JD, Moxley MA, Longmore WJ (1992). "The major glycolipid recognized by SP-D in surfactant is phosphatidylinositol". Biochemistry. 31 (48): 12183–9. PMID 1457414.
Ogasawara Y, Kuroki Y, Akino T (1992). "Pulmonary surfactant protein D specifically binds to phosphatidylinositol". J. Biol. Chem. 267 (29): 21244–9. PMID 1400434.
Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
Kuroki Y, Shiratori M, Ogasawara Y, Tsuzuki A, Akino T (1991). "Characterization of pulmonary surfactant protein D: its copurification with lipids". Biochim. Biophys. Acta. 1086 (2): 185–90. doi:10.1016/0005-2760(91)90006-4. PMID 1932100.
Crouch E, Persson A, Chang D, Heuser J (1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". J. Biol. Chem. 269 (25): 17311–9. PMID 8006040.
Schaeffer E, Guillou F, Part D, Zakin MM (1993). "A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells". J. Biol. Chem. 268 (31): 23399–408. PMID 8226864.
Kölble K, Lu J, Mole SE, Kaluz S, Reid KB (1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster". Genomics. 17 (2): 294–8. doi:10.1006/geno.1993.1324. PMID 8406480.
Crouch E, Persson A, Chang D (1993). "Accumulation of surfactant protein D in human pulmonary alveolar proteinosis". Am. J. Pathol. 142 (1): 241–8. PMC 1886847. PMID 8424457.
Crouch E, Rust K, Veile R, Donis-Keller H, Grosso L (1993). "Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1". J. Biol. Chem. 268 (4): 2976–83. PMID 8428971.
Rust K, Bingle L, Mariencheck W, Persson A, Crouch EC (1996). "Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids". Am. J. Respir. Cell Mol. Biol. 14 (2): 121–30. doi:10.1165/ajrcmb.14.2.8630261. PMID 8630261.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie AM, Epstein C, Hawgood S (1998). "Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11869–74. doi:10.1073/pnas.95.20.11869. PMC 21732. PMID 9751757.
Håkansson K, Lim NK, Hoppe HJ, Reid KB (1999). "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D". Structure. 7 (3): 255–64. doi:10.1016/S0969-2126(99)80036-7. PMID 10368295.
Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, Kliem A, Reid KB, Poustka A, Skjodt K (1999). "Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D". Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10794–9. doi:10.1073/pnas.96.19.10794. PMC 17962. PMID 10485905.
Lausen M, Lynch N, Schlosser A, Tornoe I, Saekmose SG, Teisner B, Willis AC, Crouch E, Schwaeble W, Holmskov U (1999). "Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D". J. Biol. Chem. 274 (45): 32234–40. doi:10.1074/jbc.274.45.32234. PMID 10542261.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Madsen J, Kliem A, Tornoe I, Skjodt K, Koch C, Holmskov U (2000). "Localization of lung surfactant protein D on mucosal surfaces in human tissues". J. Immunol. 164 (11): 5866–70. doi:10.4049/jimmunol.164.11.5866. PMID 10820266.
Zhang L, Ikegami M, Crouch EC, Korfhagen TR, Whitsett JA (2001). "Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure". J. Biol. Chem. 276 (22): 19214–9. doi:10.1074/jbc.M010191200. PMID 11278637.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133661 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021795 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1898081-5] Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.

[pmid1339284-6] Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284.

[entrez-7] "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D".

[pmid18355911-8] Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). "Surfactant protein D alters allergic lung responses in mice and human subjects". J. Allergy Clin. Immunol. 121 (5): 1140–1147.e2. doi:10.1016/j.jaci.2008.02.011. PMC 4145593. PMID 18355911.

[pmid10101009-9] Tino MJ, Wright JR (April 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009.

[pmid9153228-10] Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (May 1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[11] Goh, Boon Chong; Rynkiewicz, Michael J.; Cafarella, Tanya R.; White, Mitchell R.; Hartshorn, Kevan L.; Allen, Kimberly; Crouch, Erika C.; Calin, Oliviana; Seeberger, Peter H. (2013-11-13). "Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation". Biochemistry. 52 (47): 8527–8538. doi:10.1021/bi4010683. PMC 3927399. PMID 24224757.

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Surfactant protein D

Interactions

See also

References

External links

Further reading