DMBT1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DMBT1
Identifiers
Aliases DMBT1, GP340, muclin, SAG, deleted in malignant brain tumors 1
External IDs MGI: 106210 HomoloGene: 68990 GeneCards: DMBT1
RNA expression pattern
PBB GE DMBT1 208250 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004406
NM_007329
NM_017579
NM_001320644

NM_007769
NM_001347632

RefSeq (protein)

NP_001307573
NP_004397
NP_015568
NP_060049

NP_031795.2
NP_001334561
NP_031795

Location (UCSC) Chr 10: 122.56 – 122.64 Mb Chr 7: 131.03 – 131.12 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Deleted in malignant brain tumors 1 protein is a protein that in humans is encoded by the DMBT1 gene.[3][4]

Function[edit]

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.[5]

Interactions[edit]

DMBT1 has been shown to interact with Surfactant protein D.[6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A, Poustka A (Oct 1997). "DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours". Nat. Genet. 17 (1): 32–9. doi:10.1038/ng0997-32. PMID 9288095. 
  4. ^ Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Fölsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J, Schreiber S (Jun 2007). "Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion". J. Immunol. 178 (12): 8203–11. doi:10.4049/jimmunol.178.12.8203. PMID 17548659. 
  5. ^ "Entrez Gene: DMBT1 deleted in malignant brain tumors 1". 
  6. ^ Tino MJ, Wright JR (1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009. 
  7. ^ Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228. 

Further reading[edit]