Syncytin-2

ERVFRD-1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y4M
Identifiers
Aliases	ERVFRD-1, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD, endogenous retrovirus group FRD member 1, endogenous retrovirus group FRD member 1, envelope
External IDs	OMIM: 610524; MGI: 3045308; HomoloGene: 86779; GeneCards: ERVFRD-1; OMA:ERVFRD-1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	11,111,725 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	69,531,748 bp
RNA expression pattern
	Top expressed in
	placenta; ; tendon of biceps brachii; ; retinal pigment epithelium; ; gallbladder; ; right adrenal cortex; ; fundus; ; left adrenal gland; ; left adrenal cortex; ; smooth muscle tissue; ; urinary bladder;
	Top expressed in
	placenta; ; chorion; ; ovary; ; jejunum;
	More reference expression data
	n/a
Orthologs
	405754
	239167
	ENSG00000244476
	ENSMUSG00000047977
	P60508
	Q8BI41
	NM_207582
	NM_173420
	NP_997465
	NP_775596
	Wikidata
View/Edit Human	View/Edit Mouse

Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by the ERVFRD-1 gene.^[5] This protein plays a key role in the implantation of human embryos in the womb.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000244476 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047977 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HERV-FRD HERV-FRD provirus ancestral Env polyprotein".
^ Vargas A, Moreau J, Landry S, LeBellego F, Toufaily C, Rassart E, Lafond J, Barbeau B (2009). "Syncytin-2 plays an important role in the fusion of human trophoblast cells". Journal of Molecular Biology. 392 (2): 301–18. doi:10.1016/j.jmb.2009.07.025. PMID 19616006.

de Parseval N, Lazar V, Casella JF, Benit L, Heidmann T (October 2003). "Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins". Journal of Virology. 77 (19): 10414–22. doi:10.1128/JVI.77.19.10414-10422.2003. PMC 228468. PMID 12970426.
Blaise S, de Parseval N, Bénit L, Heidmann T (October 2003). "Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution". Proceedings of the National Academy of Sciences of the United States of America. 100 (22): 13013–8. doi:10.1073/pnas.2132646100. PMC 240736. PMID 14557543.
Blaise S, Ruggieri A, Dewannieux M, Cosset FL, Heidmann T (January 2004). "Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians". Journal of Virology. 78 (2): 1050–4. doi:10.1128/JVI.78.2.1050-1054.2004. PMC 368808. PMID 14694139.
Renard M, Varela PF, Letzelter C, Duquerroy S, Rey FA, Heidmann T (October 2005). "Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates". Journal of Molecular Biology. 352 (5): 1029–34. doi:10.1016/j.jmb.2005.07.058. PMID 16140326.
Malassiné A, Blaise S, Handschuh K, Lalucque H, Dupressoir A, Evain-Brion D, Heidmann T (2007). "Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells". Placenta. 28 (2–3): 185–91. doi:10.1016/j.placenta.2006.03.001. PMID 16714059.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000244476 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047977 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HERV-FRD HERV-FRD provirus ancestral Env polyprotein".

[pmid19616006-6] Vargas A, Moreau J, Landry S, LeBellego F, Toufaily C, Rassart E, Lafond J, Barbeau B (2009). "Syncytin-2 plays an important role in the fusion of human trophoblast cells". Journal of Molecular Biology. 392 (2): 301–18. doi:10.1016/j.jmb.2009.07.025. PMID 19616006.

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References

Further reading