TCEA1

TCEA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TFI, 3NDQ, 5IY7, 5IYA, 5IY6, 5IYB, 5IY8, 5IYC
Identifiers
Aliases	TCEA1, GTF2S, SII, TCEA, TF2S, TFIIS, transcription elongation factor A1
External IDs	OMIM: 601425; MGI: 1196624; HomoloGene: 55984; GeneCards: TCEA1; OMA:TCEA1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	54,022,456 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	4,968,132 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; Achilles tendon; ; optic nerve; ; caput epididymis; ; cartilage tissue; ; tail of epididymis; ; corpus epididymis; ; skin of thigh; ; parotid gland; ; lactiferous duct;
	Top expressed in
	zygote; ; fetal liver hematopoietic progenitor cell; ; tail of embryo; ; secondary oocyte; ; medial ganglionic eminence; ; parotid gland; ; lacrimal gland; ; hand; ; calvaria; ; human fetus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; protein binding; metal ion binding; nucleic acid binding;
Cellular component	nucleolus; nucleus; nucleoplasm; transcription factor TFIID complex;
Biological process	transcription elongation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of exoribonuclease activity; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6917
	21399
	ENSG00000187735
	ENSMUSG00000033813
	P23193
	P10711
	NM_006756; NM_201437
	NM_001159750; NM_001159751; NM_011541
	NP_006747; NP_958845
	NP_001153222; NP_001153223; NP_035671
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

TCEA1 has been shown to interact with GTF2H1^[8]^[9] and POLR2A.^[8]^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187735 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033813 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ DiMarco SP, Glover TW, Miller DE, Reines D, Warren ST (Feb 1997). "Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3". Genomics. 36 (1): 185–8. doi:10.1006/geno.1996.0443. PMID 8812434.
^ Park H, Baek K, Jeon C, Agarwal K, Yoo O (Mar 1994). "Characterization of the gene encoding the human transcriptional elongation factor TFIIS". Gene. 139 (2): 263–7. doi:10.1016/0378-1119(94)90767-6. PMID 8112616.
^ "Entrez Gene: TCEA1 transcription elongation factor A (SII), 1".
^ ^a ^b Archambault, J; Pan G; Dahmus G K; Cartier M; Marshall N; Zhang S; Dahmus M E; Greenblatt J (Oct 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42). UNITED STATES: 27593–601. doi:10.1074/jbc.273.42.27593. ISSN 0021-9258. PMID 9765293.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ ^a ^b Pan, G; Aso T; Greenblatt J (Sep 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. 272 (39). UNITED STATES: 24563–71. doi:10.1074/jbc.272.39.24563. ISSN 0021-9258. PMID 9305922.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Kettenberger, Hubert; Armache Karim-Jean; Cramer Patrick (Aug 2003). "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage". Cell. 114 (3). United States: 347–57. doi:10.1016/S0092-8674(03)00598-1. ISSN 0092-8674. PMID 12914699.

Interactions

References

Further reading