TOP3B

TOP3B
Identifiers
Aliases	TOP3B, TOP3B1, topoisomerase (DNA) III beta, DNA topoisomerase III beta
External IDs	OMIM: 603582; MGI: 1333803; HomoloGene: 2923; GeneCards: TOP3B; OMA:TOP3B - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	21,982,813 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	16,710,854 bp
RNA expression pattern
	Top expressed in
	middle frontal gyrus; ; frontal pole; ; stromal cell of endometrium; ; Brodmann area 10; ; canal of the cervix; ; spleen; ; right lobe of liver; ; right lobe of thyroid gland; ; right uterine tube; ; body of stomach;
	Top expressed in
	spermatocyte; ; internal carotid artery; ; superior frontal gyrus; ; external carotid artery; ; lip; ; neural tube; ; medullary collecting duct; ; spermatid; ; cerebellar cortex; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA topoisomerase type I (single strand cut, ATP-independent) activity; protein binding; isomerase activity; RNA binding; DNA topoisomerase activity;
Cellular component	condensed chromosome; nucleus;
Biological process	chromosome segregation; DNA topological change;
	Sources:Amigo / QuickGO
Orthologs
	8940
	21976
	ENSG00000100038
	ENSMUSG00000022779
	O95985
	Q9Z321
NM_001282112; NM_001282113; NM_003935; NM_001349845; NM_001349847;
	NM_001349848; NM_001349850; NM_001349851; NM_001349852
	NM_011624; NM_001326576
NP_001269041; NP_001269042; NP_003926; NP_001336774; NP_001336776;
	NP_001336777; NP_001336779; NP_001336780; NP_001336781
	NP_001313505; NP_035754
	Wikidata
View/Edit Human	View/Edit Mouse

DNA topoisomerase 3-beta-1 is an enzyme that in humans is encoded by the TOP3B gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100038 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022779 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang D, Kidd VJ (Dec 1998). "Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis". J Biol Chem. 273 (44): 28549–52. doi:10.1074/jbc.273.44.28549. PMID 9786842.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Kawasaki K, Minoshima S, Nakato E, Shibuya K, Shintani A, Schmeits JL, Wang J, Shimizu N (May 1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.
^ "Entrez Gene: TOP3B topoisomerase (DNA) III beta".

References

Further reading