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Thioredoxin interacting protein
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TXNIP ; EST01027; HHCPA78; THIF; VDUP1
External IDs OMIM606599 MGI1889549 HomoloGene38186 GeneCards: TXNIP Gene
RNA expression pattern
PBB GE TXNIP 201010 s at tn.png
PBB GE TXNIP 201008 s at tn.png
PBB GE TXNIP 201009 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10628 56338
Ensembl ENSG00000265972 ENSMUSG00000038393
UniProt Q9H3M7 Q8BG60
RefSeq (mRNA) NM_006472 NM_001009935
RefSeq (protein) NP_006463 NP_001009935
Location (UCSC) Chr 1:
145.99 – 146 Mb
Chr 3:
96.56 – 96.56 Mb
PubMed search [1] [2]

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.[1][2]


TXNIP has been shown to interact with Thioredoxin[3] and ZBTB32.[4]

Related gene problems[edit]


  1. ^ Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica Et Biophysica Acta 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474. 
  2. ^ "Entrez Gene: TXNIP thioredoxin interacting protein". 
  3. ^ Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473. 
  4. ^ Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938. 

Further reading[edit]