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Thioredoxin interacting protein
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TXNIP ; EST01027; HHCPA78; THIF; VDUP1
External IDs OMIM606599 MGI1889549 HomoloGene38186 GeneCards: TXNIP Gene
RNA expression pattern
PBB GE TXNIP 201010 s at tn.png
PBB GE TXNIP 201008 s at tn.png
PBB GE TXNIP 201009 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10628 56338
Ensembl ENSG00000265972 ENSMUSG00000038393
UniProt Q9H3M7 Q8BG60
RefSeq (mRNA) NM_006472 NM_001009935
RefSeq (protein) NP_006463 NP_001009935
Location (UCSC) Chr 1:
145.99 – 146 Mb
Chr 3:
96.56 – 96.56 Mb
PubMed search [1] [2]

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.[1][2]


TXNIP has been shown to interact with Thioredoxin[3] and ZBTB32.[4]

Related gene problems[edit]


  1. ^ Chen KS, DeLuca HF (Oct 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochim Biophys Acta 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474. 
  2. ^ "Entrez Gene: TXNIP thioredoxin interacting protein". 
  3. ^ Nishiyama, A; Matsui M; Iwata S; Hirota K; Masutani H; Nakamura H; Takagi Y; Sono H; Gon Y; Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". J. Biol. Chem. (UNITED STATES) 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. ISSN 0021-9258. PMID 10419473. 
  4. ^ Han, Seung Hyun; Jeon Jun Ho, Ju Hyang Ran, Jung Uhee, Kim Kun Young, Yoo Hyang Sook, Lee Young Ho, Song Kyu Sang, Hwang Ho Myeung, Na Yoon Sook, Yang Young, Lee Kee Nyung, Choi Inpyo (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene (England) 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. ISSN 0950-9232. PMID 12821938. 

Further reading[edit]