TXNIP

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TXNIP
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TXNIP, thioredoxin interacting protein, EST01027, HHCPA78, THIF, VDUP1
External IDs MGI: 1889549 HomoloGene: 38186 GeneCards: 10628
RNA expression pattern
PBB GE TXNIP 201010 s at tn.png

PBB GE TXNIP 201008 s at tn.png

PBB GE TXNIP 201009 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006472
NM_001313972

NM_001009935
NM_023719

RefSeq (protein)

NP_006463.3
NP_001300901.1

NP_001009935.1
NP_076208.2

Location (UCSC) Chr 1: 145.99 – 146 Mb Chr 3: 96.56 – 96.56 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.[1][2]

Interactions[edit]

TXNIP has been shown to interact with Thioredoxin[3] and ZBTB32.[4]

Related gene problems[edit]

References[edit]

  1. ^ Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474. 
  2. ^ "Entrez Gene: TXNIP thioredoxin interacting protein". 
  3. ^ Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473. 
  4. ^ Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938. 

Further reading[edit]