Talk:Adductome

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Scope

Perhaps this page should be generalized to the study of all adducts, then give DNA adducts as an example? User:BobBagwill

Definition

I have made clear improvements to the subject, well referenced, and accurate. Prior to that much was unsubstantiated, and very limited in scope. The current version, Adductome, needs work too (e.g., the definition of exposome and therefore origin of the adductome is incorrect). RedoxStress (talk) 17:36, 21 August 2023 (UTC)}}[reply]

@RedoxStress:. Thanks for your edits. I am not an expert in this field, but there seems to be a range of definitions on what the adductome includes. The narrowest definition is adducts formed between endogenous and exogenous substances. An intermediate definition also includes adducts between endogenous substances and endogenous substance activated by oxidation (i.e., reactive oxygen species) (please note that PMID 35190722 does not mention adductome). The broadest definition would also include any molecule that is the product of biosynthesis including proteins and nucleic acids. I propose that we introduce a cascade of definitions from narrow to broad. Does this sound reasonable? Boghog (talk) 19:25, 21 August 2023 (UTC)[reply]

Really the most precise (and simplest) definition of the adductome is the totality of adducts (akin to genome, proteome etc.). From where these adducts arise i.e., endogenous vs. exogenous, is a different question, and doesn't influence the definition. I'd suggest keeping the definition simple, and describing the origin of adducts separately. OK?

You're right PMID 35190722 doesn't refer to the adductome, but is referenced as the source of info concerning cellular reactive species, of the kind that can form adducts. RedoxStress (talk) 19:35, 21 August 2023 (UTC)[reply]