Talk:Flucloxacillin

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Molecule[edit]

Can anyone produce a copywrite-free public image of Flucloxacillin, eg as per [1] ? David Ruben Talk 03:14, 25 January 2006 (UTC)

Done, and I've also revised the content. -Techelf 07:58, 26 January 2006 (UTC)

Dicloxacillin[edit]

These two articles are word for word the same, interchanging only flucloxacillin and dicloxacillin. The only significant differences are the diagrams, which differ by a single atom and could be on the same page, and the drug tables. In addition, the articles already state where the two drugs differ, so all that would be required is moving the diagram and drug table of one of the drugs to the other drug page and setting up a redirect. Since these are so similar, should they be merged? Yazza 12:38, 22 May 2007 (UTC)

I would oppose a merge. --Arcadian 15:52, 22 May 2007 (UTC)

Major difference is that flucloxacillin has been associated with severe jaundice, dicloxacillin hasnt, and is thus more widely used now. 121.209.49.58 (talk) 22:50, 18 October 2009 (UTC) Jonathan

Guestion[edit]

Who developed it when? —Preceding unsigned comment added by 74.170.68.234 (talk) 00:12, 2 April 2008 (UTC)

Beecham, in the late 1960s. The first non-natural penicillins (meticillin, ampicillin, nafcillin...) were all developed by Beecham. Fvasconcellos (t·c) 00:11, 24 May 2008 (UTC)

biological origins[edit]

Is this a natural or synthetic antibiotic, and if natural which species of (presumably penicillium type) mould produces it? Samatarou (talk) 22:25, 23 May 2008 (UTC)

Like all isoxazolyl penicillins, flucloxacillin is semisynthetic; it is "built around" 6-APA (the penicillin core), which is synthesized by P. chrysogenum. You may want to read this very interesting article (which someone should really work into beta-lactam antibiotic) and this 1970 paper, one of the first to report on flucloxacillin. Fvasconcellos (t·c) 00:06, 24 May 2008 (UTC)