Talk:Gut flora

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content issue[edit]

about this:

Populations of bacteria within the gastrointestinal tract are different than those in healthy individuals. Treatment with probiotic strains of bacteria has shown to be effective, though not all strains of microorganisms confer the same benefit. Probiotic strains of bacteria have been shown to treat Irritable Bowel Syndrome and Chronic Idiopathic Constipation.[1]

References

  1. ^ Ford, Alexander C; Quigley, Eamonn M M; Lacy, Brian E; Lembo, Anthony J; Saito, Yuri A; Schiller, Lawrence R; Soffer, Edy E; Spiegel, Brennan M R; Moayyedi, Paul (2014). "Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis". The American Journal of Gastroenterology. 109 (10): 1547–1561. doi:10.1038/ajg.2014.202. ISSN 0002-9270. 

What does "Populations of bacteria within the gastrointestinal tract are different than those in healthy individuals." mean? What is being compared? And please use pmids in refs. Thanks. Jytdog (talk) 01:05, 12 May 2016 (UTC)

Almost always, what's being compared is the population makeup at the family, order, or phylum level, reconstructed by 16S ribosomal RNA: e.g. 60% Bacteriodales, 15% Firmicutes, 5% Enterobacteria, etc. One has to be careful with "those in healthy individuals", because there's a very wide range of "healthy" gut microbiomes, governed by history, immune cross-talk, diet, and much more. I'm no expert, but I did a lot of reading on this last semester and can give this article some attention in the near future. FourViolas (talk) 19:00, 15 June 2016 (UTC)
You are not answering the question either, fwiw. Jytdog (talk) 21:10, 15 June 2016 (UTC)
Sorry. The cited review states that The cause of these functional bowel disorders remains unclear, but visceral hypersensitivity (4,5), disturbances in gastrointestinal (GI) flora (6,7), and chronic immune activation leading to a low-grade mucosal inflammation (8,9,10,11) have all been implicated in the pathogenesis of [irritable bowel syndrome and chronic idiopathic constipation]. References 6 and 7 are to Kassinen et al 2007 and Attaluri et al 2010, which show respectively that 16S-determined gut bacterial population structure is significantly different, and distinguishable a postiori by Bayesian analysis, from population structure in non-IBS controls; and that the presence of methanogenic bacteria (in phenotypically-detectable numbers) in the gut is associated with non-IBS constipation.
So, again, what's being compared is which kinds of gut bacteria are present in eubiotic vs. disease states, and in what proportion. FourViolas (talk) 03:27, 16 June 2016 (UTC)
yep. Jytdog (talk) 07:50, 16 June 2016 (UTC)

Human microbiota[edit]

Content about gut flora cropped up in the Human microbiota article that was not here. Am merging that content here and will blend it, then will up date the lead of this article, then will copy the lead of this article to Human microbiota#Gut flora with a link to main, per WP:SYNC Jytdog (talk) 20:25, 18 June 2016 (UTC)