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|WikiProject Medicine / Toxicology||(Rated Start-class, Low-importance)|
In the section Premature aging there are claims of dangers with references that have nothing to do with the dangers. The narrative there is simple speculation. — Preceding unsigned comment added by 220.127.116.11 (talk) 16:15, 14 November 2016 (UTC)
Also, all the references used on this page are for Comparative Safety Statistics, which is relevant for iron, not Vitamin D. I'm not the one to do it, but it seems that some or most of the info from the Vitamin D article should be moved here, or this page should be eliminated.
I think the other page may have some inaccuracies also. This study, from January 2007, attempts to delve into Vitamin D toxicity: http://www.ajcn.org/cgi/content/full/85/1/6
The 4,000,000 IU number so commonly bandied about is attributed in said article to be from an animal study. I believe the study establishes a conservative lower level of toxicity at 77,000 IU, or 1925 µg. This is consistent with what I've read before. —Preceding unsigned comment added by Rhodescus (talk • contribs) 04:44, 23 August 2008 (UTC)
I went ahead and changed the text. Further proposed changes (I can't find the reference) - hypercalcaemia at too high a level is a medical emergency and can induce coma or death. That isn't listed here, I can't remember where I read it.
Sorry I didn't sign my last post.
"Although taking excessive amounts of cod liver oil over months or years could produce an overdose in theory, it is almost always associated with forms of vitamin D that require a doctor's prescription."
Um... vitamin D3 doesn't require a doctor prescription, D2 is weaker (at least on humans), and I don't think any of the other types (D1, D4, D5) are commonly used at all, nor have I read anything to suggest that they're vastly more potent, so I'm curious as which "forms" the author is referring to. Perhaps the author meant high dosage--Stoss therapy is the only thing I can think of, but there's no such (FDA-approved) prescription in the USA... though it may be recognized in New Zealand and/or Australia.
Am removing the reference to "prescription" Vitamin D, though the original author is free to re-insert it so long as he/she explains the statement.
- Just to let you know, there is a prescription form. D3 does partially contain some of the active form, 1,25 dihydroxycholecalciferol, but pure supplementation of the active form is a prescription medication. Rmosler | ● 15:34, 16 December 2010 (UTC)
Orphaned references in Hypervitaminosis D
I check pages listed in Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of Hypervitaminosis D's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.
Reference named "pmid18417640":
- From Hypovitaminosis D: Melamed ML, Muntner P, Michos ED; et al. (2008). "Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004". Arteriosclerosis, Thrombosis, and Vascular Biology. 28 (6): 1179–85. doi:10.1161/ATVBAHA.108.165886. PMC . PMID 18417640. Unknown parameter
- From Vitamin D: Melamed, ML; Muntner, P; Michos, ED; Uribarri, J; Weber, C; Sharma, J; Raggi, P (2008). "Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004". Arteriosclerosis, thrombosis, and vascular biology. 28 (6): 1179–85. doi:10.1161/ATVBAHA.108.165886. PMC . PMID 18417640.
I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT⚡ 17:48, 26 March 2010 (UTC)
Massive loss of data
The units in the article are confusing. In one place it's IU, in another it's nmol/L. I think it creates a lot of confusion, at least for people who have no professional knowledge on the subject matter, and should be clarified. — Preceding unsigned comment added by 18.104.22.168 (talk) 20:22, 7 December 2014 (UTC)
Long-term effects of oral supplementation
I find the following sentence questionable in itself (seems like a statement of opinion and even suggests it is farfetched), but I feel like it does not belong in this section either: "It has been argued that ingestion of vitamin D in large amounts was achieved in the process of grooming by furry human ancestors and that from UV-exposed human skin secretions early humans ingested vitamin D by licking the skin; however, this putative ingestion of vitamin D by early humans is not quantified."
Why does the following discussion appear here?
"A loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. Another name for a single high-dose oral vitamin D(3) is stoss therapy. A single oral dose of 600,000 IU of cholecalciferol rapidly increases levels of calcifediol, or 25-deoxy-cholecalciferol [25(OH)D], and reduces levels of parathyroid hormone (PTH) in young people with vitamin D deficiency. A cholecalciferol loading dose guideline for vitamin D-deficient adults has been developed."
This article is about hypervitaminosis. This discussion applies to vitamin D deficiency. While well written, this content should be moved to the vitamin D deficiency article. Dryphi (talk) 14:53, 23 February 2016 (UTC)