Talk:Lanosterol 14 alpha-demethylase

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A little inaccurate. The demethylase is but one enzyme in the pathway from lanosterol to other sterols - these include cholesterol in animal cells, ergosterol in fungi, and stigmasterol in plants. The pathways all begin with squalene.

Phil Scrutinator (talk) 11:20, 17 March 2008 (UTC)[reply]

Off topic

I'm sorry, but this is really not well tied in with this article:

Historical significance and disease relevance

Since the early beginnings of crop growing, fungal pathogens have posed a significant threat to yields. Records documenting fungal infections of wheat residues date back to 1300 B.C.^[1] Today, it is estimated that fungi and bacteria are responsible for approximately 16% of losses in major crops.^[2] Aside from jeopardizing plant viability, fungal pathogens can also harm animal species by producing mycotoxins or causing invasive and life-threatening infections (Becher et al). The clinical relevance of this phenomenon has increased dramatically in light of recent advances within the health care sector; improved survival of immunocompromised patients such as those undergoing transplantation or suffering from AIDS or cancer has left a growing number of individuals susceptible to fungal infections.^[3] The search for potent antifungal interventions ultimately led scientists to explore the role of 14 α-demethylase in maintaining the integrity of fungal cell membranes (Becher et al).

The only actual link this has with our text is that the pathogens made people want to explore the role of the enzyme, which is pretty weak when you consider that they would have explored the role anyway because that's what scientists do. Some of the background might be integrable into a more general fungus or stem rust article, etc.

I would of course more than welcome data about

diseases treated by inhibiting this enzyme
crop treatments that inhibit this enzyme
data about the actual funding that was written to benefit this line of research specifically, such as from non-profits or government earmarks
etc.

Just, please, remember this is an article narrowly about the subject, not a talk about your research for the past year(s) where you're trying to ease your audience into the mood. Wnt (talk) 18:18, 26 July 2014 (UTC)[reply]

References

^ Kislev, ME. "Stem Rust of Wheat 3300 Years Old Found in Israel." Science. 1982, 216(4549):993–994
^ Oerke, EC. "Crop Losses to Pests." J Agr Sci. 2006, 144:31–43.
^ Richardson, MD. "Changing Patterns and Trends in Systemic Fungal Infections." J Antimicrob Chemother. 2005, 56:i5–i11.

[1] Kislev, ME. "Stem Rust of Wheat 3300 Years Old Found in Israel." Science. 1982, 216(4549):993–994

[2] Oerke, EC. "Crop Losses to Pests." J Agr Sci. 2006, 144:31–43.

[3] Richardson, MD. "Changing Patterns and Trends in Systemic Fungal Infections." J Antimicrob Chemother. 2005, 56:i5–i11.

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