Talk:Persister cells

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Merge with multidrug resistance?

Since this is an orphan page, and I don't see it explaining the difference between it and multidrug resistance, and the google hit numbers are vastly different (multidrug resistance being higher), maybe it's a good idea to merge these two together if the concepts are not distinctively different enough? Keith Galveston (talk) 09:23, 28 November 2009 (UTC)[reply]

No, this page should remain as a seperate entry: Multidrug resistance differs from multidrug tolerance. ^[1] Multidrug resistance refers to a genetic trait (resistance) newly acquired by mutation or gene transfer. In contrast to this, multidrug tolerance refers to a physiological differentiation state in which a subpopulation of microorganisms adopts a dormant, non-growing state that renders them insensitive (refractory or tolerant) to antimicrobial drugs such as antibiotics. It is also called 'antibiotic tolerance'. When the microbes resume growth, the majority of the population remains sensitive to the antibiotic. I will edit the page to better explain this fundamental difference and add references. --Ckocks71 (talk) 22:30, 23 February 2010 (UTC)[reply]

References

^ Lewis, K. (2007) Persister cells, dormancy and infectious disease. Nat. Rev. Microbiol. 5:48-56.

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[1] Lewis, K. (2007) Persister cells, dormancy and infectious disease. Nat. Rev. Microbiol. 5:48-56.

[1]