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Wiki Education Foundation-supported course assignment

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 27 January 2020 and 8 May 2020. Further details are available on the course page. Student editor(s): 291653ABC.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 02:26, 18 January 2022 (UTC)[reply]

Wiki Education Foundation-supported course assignment

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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Gaylamarlohahn, Allanwlevy, Brendaw8, Jesslin2411, Ireneyoungaha, Ekhar17, Steffikwok, Kyrawade, ElegantNiceFlamingo, Shea.k, Illiterato, Renee Sweeney, Darren.y.huang, Amberlyjoslinwang, M.hom, GhasMak, Kienn313.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 06:47, 17 January 2022 (UTC)[reply]

Comment

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"PKU is totally benign if a diet free from the amino acid is maintained. Depending on the mutation involved, this results in reduced or zero conversion of phenylalanine to tyrosine, and phenylalanine concentrations increase to toxic levels, causing damage at several locations in the body."

This quote is confusing.

Focus 'Mechanism' on the mechanism, not on PKU

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This section should be about how one gene can control several traits. We get started down this road by noting that PKU can cause two unrelated traits: mental retardation and pigmentation. However, there's no explanation of the mechanism for this. The fact that PKU can be benign under certain circumstances is irrelevant.

The entire second paragraph of the Mechanism section, except the first sentence, should be deleted, and replaced with an explanation of how one enzyme can affect both mental retardation and pigmentation.

Asteen 16:06, 14 November 2007 (UTC)[reply]


Opening line, "This can become a problem when selection on one trait favors one specific version of the gene (allele), while the selection on the other trait favors another allele."

"Problem" is highly ambiguous. What does 'problem' refer to in the context of evolutionary biology? Pleiotropy may create complications/complexities in this context, but 'problem' is meaningless.

HARDGREG (talk) 16:44, 12 December 2010 (UTC)[reply]

Comment

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The examples are mostly of diseases and I don't want pleiotropy to come off as a disease. Can we add sections on plant morphology or non disease causing effects?

Comment

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Can some examples be included in this article? 128.2.225.179 (talk) 20:52, 7 December 2012 (UTC) Steffikwok (talk) 22:30, 8 November 2016 (UTC)[reply]

Evo-devo is missing

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This article needs updating to reflect evo-devo understanding that (among other things) one cis-regulatory element can control multiple genes and thus have pleiotropic effects. Chiswick Chap (talk) 05:33, 3 January 2018 (UTC)[reply]

Thanks, Yoda

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Concluding sentence in current lead:

Genetic correlations and responses to selection most often exemplify pleiotropy.

genetic correlations and responses
vague noun phrase of arbitrary, inclusive scope
to selection
kitchen-sink qualifier
most often
modulo the unspoken denominator behind the curtain
exemplify
lazy hazy abstract main verb
pleiotropy
finally a word I fully understood (at least I thought I did until this sentence landed)

Hagenaars and Harris

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As a second item, here's a recent paper (or its secondary discussion) well worth citing:

[Edit] Here's one such secondary discussion:

MaxEnt 13:57, 11 July 2018 (UTC)[reply]

Wiki Education assignment: Comparative Developmental Biology

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 8 January 2024 and 19 April 2024. Further details are available on the course page. Student editor(s): A1243617202 (article contribs).

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