Talk:Pyrimidine dimer

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Proposed merger

I'm proposing that Thymine dimer be merged into this page. All the information on the thymine dimer page is pertinent for other pyrimidine dimers. While thymine dimers are the most commonly formed, CT dimers and CC dimers are also formed at significant rates,^[1] and the CC and CT dimers are actually more likely to result in mutations due to the "A rule" that causes As to be inserted when the template is doubtful^[2]. I can add the material from Thymine dimer to this page and then add a discussion based on the references above, and I think it will be more informative than having the two articles separate. Agathman (talk) 16:00, 29 May 2009 (UTC)[reply]

Okay, I've set up a draft of the proposed new Pyrimidine Dimer page here: User:Agathman/CPDs_Working_Page. There has been no comment since the merger proposal went up, almost 3 months ago, so I'm about ready to replace the Pyrimidine dimer page with my draft and replace the Thymine dimer page with a redirect to that one. If anyone cares, please say so soon.

Sounds good. I will rescue the highly chemical bit abuot cyclobutanes. Thymine dimer is not very impressive as it stands, so your work is a real improvement.--Smokefoot (talk) 16:23, 16 August 2009 (UTC)[reply]

Although this article is about a technical subject, the lead should be made easier to understand. For example, the word “translesion,” although correct, is not in the dictionary. Bwrs (talk) Bwrs (talk) 03:34, 1 December 2009 (UTC)[reply]

References

^ Mouret, S; Baudouin, C; Charveron, M; Favier, A; Cadet, J; Douki, T (2006). "Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation" (Free full text). Proceedings of the National Academy of Sciences of the United States of America. 103 (37): 13765–70. doi:10.1073/pnas.0604213103. ISSN 0027-8424. PMC 1564232. PMID 16954188. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
^ Brash DE, Rudolph JA, Simon JA; et al. (1991). "A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10124–8. PMC 52880. PMID 1946433. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Not 6-4 and left handed DNA

In the figure illustrating the types of dimers, 6-4 photoproduct is shown incorrectly. What is shown is a so-called "spore photoproduct" (http://www.photobiology.com/photoiupac2000/nichol/index.htm). The structure of 6-4 is quite different (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A3935, Fig. 15.2) —Preceding unsigned comment added by 89.251.107.24 (talk) 11:44, 12 June 2010 (UTC)[reply]

The SP product is okay according to 2006 paper by Buis et al ... doi:10.1074/jbc.M603931200. Your ref (http://www.photobiology.com/photoiupac2000/nichol/index.htm) gets its structure for Figure 15.2 from Taylor et al J Am Chem Soc. 1987; 109: 2834–2835, which might be obsolete. Medical sources occasionally are way behind on their chemistry.--Smokefoot (talk) 01:24, 16 November 2010 (UTC)[reply]

The image 'DNA_UV_mutation.svg‎' shows a left-handed DNA, it should be a right handed DNA. This a fundamental mistake.

Assessment comment

The comment(s) below were originally left at Talk:Pyrimidine dimer/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

The final diagram is in error. The ring double bonds in the thiamines have remained, despite the formation of the dimer. I am not expert enough to know the exact arrangement, but do know that 5-bonnded carbon is wrong. I agree, there should not be a double bond in the ring of the two thymine dimers anymore. Someone needs to edit the diagram. —Preceding unsigned comment added by 128.220.159.20 (talk) 17:17, 10 December 2007 (UTC)[reply]

Substituted at 21:56, 26 June 2016 (UTC)

Perhaps the citation needed for most melanomas deriving from pyrimidine dimers

Hart et al. (1977) reported that thyroid tumors that developed from transplanted UV-C-irradiated thyroid cells were highly photoreactivable in the small tropical fish Poecilia formosa showing that pyrimidine dimers can induce tumors. R.B. Setlow et al. (1989) later found that PR treatment of a platyfish-swordtail hybrid (Xiphophorus) reduced the incidence of UV-B-induced melanoma to background levels, and Ley et al. (1989) found PR of melanoma induction in the skin of M. domestica. These results showed that CPDs produced by either UV-B or UV-C can act as complete carcinogens for melanoma induction. Cook & McGrath (1967) had earlier failed to find PR activity in skin of the mouse or rabbit.

http://photobiology.info/Jagger.html — Preceding unsigned comment added by 184.66.250.169 (talk) 00:11, 5 April 2017 (UTC)[reply]

Proposed merge of Direct DNA damage into Pyrimidine dimer

Same topic, more focused on human skin, less well-written Artoria 2e5 🌉 12:39, 17 January 2021 (UTC)[reply]

Merger complete. Klbrain (talk) 04:41, 4 September 2022 (UTC)[reply]

Wiki Education assignment: History of Science to Newton

This article was the subject of a Wiki Education Foundation-supported course assignment, between 17 January 2023 and 11 May 2023. Further details are available on the course page. Student editor(s): BigPoppa1923 (article contribs).

— Assignment last updated by BigPoppa1923 (talk) 02:13, 18 April 2023 (UTC)[reply]

[1] Mouret, S; Baudouin, C; Charveron, M; Favier, A; Cadet, J; Douki, T (2006). "Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation" (Free full text). Proceedings of the National Academy of Sciences of the United States of America. 103 (37): 13765–70. doi:10.1073/pnas.0604213103. ISSN 0027-8424. PMC 1564232. PMID 16954188. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

[pmid1946433-2] Brash DE, Rudolph JA, Simon JA; et al. (1991). "A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10124–8. PMC 52880. PMID 1946433. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

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