Tetrahymanol synthase
| Tetrahymanol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.123 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Tetrahymanol synthase (EC 4.2.1.123, squaleneatetrahymanol cyclase) is an enzyme with systematic name squalene hydro-lyase (tetrahymanol forming).[1][2] This enzyme catalyses the following chemical reaction
- tetrahymanol squalene + H2O
The reaction occurs in the reverse direction.
This enzyme is isolated from Tetrahymena protozoans.
References
- ^ Saar, J.; Kader, J.C.; Poralla, K.; Ourisson, G. (1991). "Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila". Biochim. Biophys. Acta. 1075: 93–101. doi:10.1016/0304-4165(91)90080-z. PMID 1892870.
- ^ Giner, J.L.; Rocchetti, S.; Neunlist, S.; Rohmer, M.; Arigoni, D. (2005). "Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis". Chem. Commun. (24): 3089–3091. doi:10.1039/b504300j. PMID 15959594.
External links
- Tetrahymanol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)