Thrombospondin 3

THBS3
Identifiers
Aliases	THBS3, TSP3, thrombospondin 3
External IDs	OMIM: 188062; MGI: 98739; HomoloGene: 5159; GeneCards: THBS3; OMA:THBS3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,209,051 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,134,144 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; tibia; ; right coronary artery; ; left uterine tube; ; tibial nerve; ; canal of the cervix; ; ascending aorta; ; left coronary artery; ; anterior pituitary; ; gastric mucosa;
	Top expressed in
	spermatocyte; ; lip; ; ankle; ; right lung lobe; ; ankle joint; ; esophagus; ; spermatid; ; uterus; ; belly cord; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; heparin binding; extracellular matrix structural constituent;
Cellular component	perinuclear region of cytoplasm; extracellular region; extracellular matrix; extracellular space; collagen-containing extracellular matrix;
Biological process	growth plate cartilage development; ossification involved in bone maturation; cell-matrix adhesion; cell adhesion; bone trabecula formation; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	7059
	21827
	ENSG00000169231
	ENSMUSG00000028047
	P49746
	Q05895
	NM_001252607; NM_001252608; NM_007112
	NM_013691
	NP_001239536; NP_001239537; NP_009043
	NP_038719
	Wikidata
View/Edit Human	View/Edit Mouse

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.^[5]^[6]

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation.^[7] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169231 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028047 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. PMID 1601886.
^ ^a ^b "Entrez Gene: THBS3 thrombospondin 3".
^ Hankenson, Kurt (July 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMID 15964815. Retrieved 24 February 2015.

References

Further reading