Tinospora cordifolia (common names gurjo, heart-leaved moonseed, guduchi or giloy) is a herbaceous vine of the family Menispermaceae indigenous to tropical regions of the Indian subcontinent. Despite centuries of use in traditional medicine to treat various disorders, there is no clinical evidence that it has an effect on any diseases.
It is a large, deciduous, extensively-spreading, climbing shrub with several elongated twining branches. Leaves are simple, alternate, and exstipulate with long petioles up to 15 cm (6 in) long which are roundish and pulvinate, both at the base and apex with the basal one longer and twisted partially and half way around. It gets its name heart-leaved moonseed by its heart-shaped leaves and its reddish fruit. Lamina are broadly ovate or ovate cordate, 10–20 cm (4–8 in) long or 8–15 cm (3–6 in)broad, seven nerved and deeply cordate at base, membranous, pubescent above, whitish tomentose with a prominent reticulum beneath. Flowers are unisexual, small on separate plants and appearing when the plant is leafless, greenish-yellow on axillary and terminal racemes. Male flowers are clustered, but female flowers are usually solitary. It has six sepals in two series of three each. The outer ones are smaller than the inner. It has six petals which are smaller than sepals, obovate, and membranous. Fruits aggregate in clusters of one to three. They are ovoid smooth drupelets on thick stalks with sub terminal style scars, scarlet or orange colored.
Endophytic fungi colonize the living, internal tissues of their host without causing any harmful effects. A recent study has shown that 29 endophytes belonging to different taxa were present in the samples collected from T. cordifolia.
Extracts of the endophytic fungus Nigrospora sphaerica obtained from T. cordifolia were found to have insecticidal properties against the Oriental leafworm moth (Spodoptera litura), a polyphagous pest.
Tinospora contains diverse phytochemicals, including alkaloids, phytosterols, glycosides, and mixed other chemical compounds. Columbin, tinosporaside, jatrorhizine, palmatine, berberine,  tembeterine, tinocordifolioside, phenylpropene disaccharides, choline, tinosporic acid, tinosporal, tinosporon, and tinosporide have been isolated from Tinospora cordifolia. 
In Ayurveda, Tinospora has been used over centuries to treat various diseases. Due to inadequate design or other weaknesses of clinical research on Tinospora, there is no high-quality scientific evidence that it has any anti-disease effect, and is not used as a prescription drug.
- "Tinospora". Drugs.com. 15 July 2019. Retrieved 5 September 2019. CS1 maint: discouraged parameter (link)
- Sinha, Kirti; Mishra, N P; Singh, J; Khanuja, S P S (July 2004). "Tinospora cordifolia (Guduchi), a reservoir plant for therapeutic applications: A Review". Indian Journal of Traditional Knowledge. 3 (3): 257–70.
- Mishra, Ashish; Gond, Surendra K.; Kumar, Anuj; Sharma, Vijay K.; Verma, Satish K.; Kharwar, Ravindra N.; Sieber, Thomas N. (2012). "Season and Tissue Type Affect Fungal Endophyte Communities of the Indian Medicinal Plant Tinospora cordifolia More Strongly than Geographic Location". Microbial Ecology. 64 (2): 388–98. doi:10.1007/s00248-012-0029-7. PMID 22430503. S2CID 10738815.
- Thakur, Abhinay; Kaur, Sanehdeep; Kaur, Amarjeet; Singh, Varinder (2012). "Detrimental effects of endophytic fungus Nigrospora sp. on survival and development of Spodoptera litura". Biocontrol Science and Technology. 22 (2): 151–61. doi:10.1080/09583157.2011.646952. S2CID 85075708.
- Mohan, Mohind C.; Abhimannue, Anu P.; Kumar B, Prakash (15 April 2017). "Identification and Characterization of Berberine in Tinospora cordifolia by Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry (LC MS/MS Q-tof) and Evaluation of its anti Inflammatory Potential". Pharmacognosy Journal. 9 (3): 350–355. doi:10.5530/pj.2017.3.59.
- K, Swaminathan; Uc, Sinha; Rk, Bhatt; Bk, Sabata; Ss, Tavale (1989-01-15). "Structure of tinosporide, a diterpenoid furanolactone from Tinospora cordifolia Miers". Acta crystallographica.Section C, Crystal structure communications. PMID 2610955. Retrieved 2020-09-16.
- Kumar P, Kamle M, Mahato DK, Bora H, Sharma B, Rasane P, Bajpai VK. Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies. Curr Pharm Biotechnol. 2020;21(12):1165-1175. doi:10.2174/1389201021666200430114547 PMID 32351180