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Trans-feruloyl-CoA hydratase

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trans-feruloyl-CoA hydratase
Identifiers
EC no.4.2.1.101
CAS no.197462-62-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a trans-feruloyl-CoA hydratase (EC 4.2.1.101) is an enzyme that catalyzes the chemical reaction

4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA trans-feruloyl-CoA + H2O

Hence, this enzyme has one substrate, 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA, and two products, trans-feruloyl-CoA and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming). This enzyme is also called trans-feruloyl-CoA hydro-lyase (incorrect).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2J5I.

References

  • Narbad A, Gasson MJ. "Metabolism of ferulic acid via vanillin using a novel CoA-dependent pathway in a newly-isolated strain of Pseudomonas fluorescens". Microbiology. 144 (5): 1397–405. doi:10.1099/00221287-144-5-1397. PMID 9611814.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Pometto AL III, Crawford DL (1983). "Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus". Appl. Environ. Microbiol. 45 (5): 1582–5. PMC 242504. PMID 6870241.