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Transmembrane protein 175

From Wikipedia, the free encyclopedia

Transmembrane protein 175
Identifiers
SymbolTMEM175
PfamPF06736
InterProIPR010617
TCDB1.A.78
OPM superfamily467
OPM protein5vre
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Transmembrane protein 175
Identifiers
SymbolTMEM175
Alt. symbolsMGC4618
NCBI gene84286
HGNC28709
RefSeqNM_032326
UniProtQ9BSA9
Other data
LocusChr. 4 p16.3
Search for
StructuresSwiss-model
DomainsInterPro

Transmembrane protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many orthologs across eukaryotes.

Expression

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Based on human and mouse EST profiles and a human tissue GEO profile, TMEM175 appears to be expressed at a relatively high level (75-98%) in normal tissues.[1][2] TMEM175 appears to be down regulated in stage three ovarian cancer.[3]

Homology

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Transmembrane protein 175 has no paralogs. It does have orthologs within eukaryotes. The following table presents some of the orthologs found using searches in BLAST[4] and BLAT.[5] This list does not contain all of the orthologs for TMEM175. It is meant to display the diversity of species for which orthologs are found.

Scientific name Common Name Accession Number Sequence Length Percent Identity Percent Similarity
Homo Sapiens Human NP_115702.1 504 - -
Pan troglodytes Chimp XP_001141076 504 92 93
Pongo abelii Orangutan XP_002814537 231 99 99
Macaca mulatta Rhesus XP_001085173.1 403 96 98
Callithrix jacchus Marmoset XP_002746113.1 472 83 87
Bos taurus Cow NP_001069081.1 479 77 82
Ailuropoda melanoleuca Panda XP_002924455.1 498 81 87
Equus caballus Horse XP_001488271.1 499 81 86
Rattus norvegicus Rat NP_001014013.1 499 82 88
Mus musculus Mouse NP_082499.3 499 81 88
Monodelphis domestica Opossum XP_001377424.1 502 67 80
Ornithorhynchus anatinus Platypus XP_001514176 499 68 82
Gallus gallus Chicken NP_001006582.1 501 64 78
Sceloporus occidentalis Lizard - 417 56 66
Taeniopygia guttata Zebra Finch XP_002187908.1 496 66 79
Danio rerio Zebra Fish NP_001093545.1 520 62 76
Branchiostoma floridae Lancelet XP_002596272 409 31 50
Ciona intestinalis Sea Squirt XP_002122718 494 27 50
Nematostella vectensis Starlet Sea Anemone XP_001630719 489 28 49

Predicted Post-Translational Modification

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Using various tools at ExPASy[6] the following are possible post-translational modifications for TMEM175.

  • 5 possible CK2 phosphorylation sites
  • 2 possible PKC phosphorylation sites
  • N-myristoylation sites around transmembrane regions

The N-myristoylation sites are conserved in vertebrates.

References

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  1. ^ EST Profile Viewer- Human
  2. ^ EST Profile Viewer- Mouse
  3. ^ [Partheen K, Levan K, Osterberg L, Horvath G (November 2006). "Expression analysis of stage III serous ovarian adenocarcinoma distinguishes a sub-group of survivors". European Journal of Cancer. 42 (16): 2846–54. doi:10.1016/j.ejca.2006.06.026. PMID 16996261.
  4. ^ NCBI BLAST: Basic Local Alignment Search Tool
  5. ^ BLAT Search Genome[permanent dead link]
  6. ^ ExPASy Proteomics Server

Further reading

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